دورية أكاديمية
LDL lowering effect of PCSK9 inhibition is reduced in women
| العنوان: | LDL lowering effect of PCSK9 inhibition is reduced in women |
|---|---|
| المؤلفون: | Myasoedova V. A., Rimbert A., Camera M., Le May C., Capoulade R., Cariou B., Poggio P. |
| المساهمون: | V.A. Myasoedova, A. Rimbert, M. Camera, C. Le May, R. Capoulade, B. Cariou, P. Poggio |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Genetic, LDL reduction, PCSK9 inhibitor, Sex difference, Settore MED/50 - Scienze Tecniche Mediche Applicate |
| الوصف: | Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of plasma low-density lipoprotein cholesterol (LDL-C) concentration, and its inhibition reduces the risk of atherosclerotic cardiovascular disease (ASCVD). We aimed to assess the sex-differential effect of either pharmacological or genetic inhibition of PCSK9 on LDL-C levels. Methods and results We meta-analyzed six real-life studies (1216 men and 641 women) that investigated the effects of PCSK9 monoclonal antibodies (mAbs) on LDL-C reduction in men and women. Despite higher LDL-C levels in women at baseline [mean difference (MD) = 17.4 mg/dL, P < 0.0001, women = 175 mg/dL vs. men = 152 mg/dL], the LDL-C reduction under PCSK9 mAb treatment was significantly greater in men (MD = 7.6 mg/dL, 95% confidence interval: 2.7–12.4, P = 0.002) than in women. We tested the sex-related association of the loss-of-function variant PCSK9-R46L with LDL-C plasma levels in 382 813 individuals (219 301 women and 163 512 men) free of lipid-lowering drugs from the UK Biobank general population cohort. The magnitude of LDL-C reduction was larger in men than in women (mean LDL-C difference: –35 mg/dL vs. –26 mg/dL, when comparing homozygous carriers with non-carriers in men and women, respectively). The relationship between PCSK9-R46L and LDL-C was significantly dependent on sex (P for interaction = 7.2e–04). Conclusion These results demonstrate by complementary approaches that the decrease in LDL-C mediated by PCSK9 inhibition is slightly, but significantly, less marked in women than in men. These data reinforce the need for specific studies to develop sex-specific recommendations for the management of ASCVD in women. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36722156; info:eu-repo/semantics/altIdentifier/wos/WOS:000935291800001; volume:9; issue:4; firstpage:337; lastpage:342; numberofpages:6; journal:EUROPEAN HEART JOURNAL. CARDIOVASCULAR PHARMACOTHERAPY; https://hdl.handle.net/2434/1029772Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85149715815 |
| DOI: | 10.1093/ehjcvp/pvad009 |
| الإتاحة: | https://doi.org/10.1093/ehjcvp/pvad009Test https://hdl.handle.net/2434/1029772Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A8C2A6A3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjcvp/pvad009 |
|---|