دورية أكاديمية
Expert consensus on the treatment of patients with adult-onset still's disease with the goal of achieving an early and long-term remission
| العنوان: | Expert consensus on the treatment of patients with adult-onset still's disease with the goal of achieving an early and long-term remission |
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| المؤلفون: | Giacomelli R., Caporali R., Ciccia F., Colafrancesco S., Dagna L., Govoni M., Iannone F., Leccese P., Montecucco C., Pappagallo G., Pistone G., Priori R., Ruscitti P., Sfriso P., Cantarini L., Belfiore N., Bernardi C., Gabini M., Bettio S., Brucato A., Italiano G., Cantatore F. P., Iacono D., Pantano I., Tirri E., Ursini F., Monaco A. L., Caso F., Quartuccio L., Chimenti M. S., Gattamelata A., Gremese E., Paroli M., Picchianti-Diamanti A., Sebastiani G. D., Favalli E., Sulli A., Frassi M., Faggioli P., Foti R., Campochiaro C., Cavalli G., Tomelleri A., Manara M., De Stefano L., De Angelis R., Parisi S., Lopalco G., Piga M., Marotto D., Colaci M., Padula A., Guggino G., Emmi G., Baldini C., Sota J., Vitale A., Berti A., Bartoloni E., Grava C., Bindoli S., Vitetta R. |
| المساهمون: | Giacomelli, R., Caporali, R., Ciccia, F., Colafrancesco, S., Dagna, L., Govoni, M., Iannone, F., Leccese, P., Montecucco, C., Pappagallo, G., Pistone, G., Priori, R., Ruscitti, P., Sfriso, P., Cantarini, L., Belfiore, N., Bernardi, C., Gabini, M., Bettio, S., Brucato, A., Italiano, G., Cantatore, F. P., Iacono, D., Pantano, I., Tirri, E., Ursini, F., Monaco, A. L., Caso, F., Quartuccio, L., Chimenti, M. S., Gattamelata, A., Gremese, E., Paroli, M., Picchianti-Diamanti, A., Sebastiani, G. D., Favalli, E., Sulli, A., Frassi, M., Faggioli, P., Foti, R., Campochiaro, C., Cavalli, G., Tomelleri, A., Manara, M., De Stefano, L., De Angelis, R., Parisi, S., Lopalco, G., Piga, M., Marotto, D., Colaci, M., Padula, A., Guggino, G., Emmi, G., Baldini, C., Sota, J., Vitale, A., Berti, A., Bartoloni, E., Grava, C., Bindoli, S., Vitetta, R. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Udine: CINECA IRIS |
| مصطلحات موضوعية: | Adult-onset Still's disease, Delphi method, Expert opinion statement, Treatment algorithm |
| الوصف: | We performed a comprehensive systematic targeted literature review and used the Delphi method to formulate expert consensus statements to guide the treatment of adult-onset Still's disease (AOSD) to achieve an early and long-term remission. Seven candidate statements were generated and reached consensus in the first round of voting by the panel of experts. We postulate: (i) In patients with AOSD with predominant arthritis at onset who achieved no disease control with glucocorticoids (GCs), the use of methotrexate can be considered, whereas the use of cyclosporin A and low-dose GCs should not (Statements 1–3); (ii) In patients with AOSD with poor prognostic factors at diagnosis, an IL-1 inhibitor (IL-1i) in addition to GCs should be taken into consideration as early as possible (Statement 4); (iii) A switch to an IL-6 inhibitor (IL-6i) may be considered in patients with AOSD with prevalent joint involvement, who are unresponsive or intolerant to IL-1i (Statement 5); (iv) Drug tapering or discontinuation may be considered in patients who achieved a sustained clinical and laboratory remission with IL-1i (Statement 6); (v) In patients with AOSD who failed to attain a good clinical response with an IL-1i, switching to an IL-6i may be considered in alternative to a different IL-1i. TNF-inhibitors may be considered as a further choice in patients with a prominent joint involvement (Statement 7). These statements will help clinicians in treatment decision making in patients with AOSD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | firstpage:103400; journal:AUTOIMMUNITY REVIEWS; https://hdl.handle.net/11390/1267525Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174732057 |
| DOI: | 10.1016/j.autrev.2023.103400 |
| الإتاحة: | https://doi.org/10.1016/j.autrev.2023.103400Test https://hdl.handle.net/11390/1267525Test |
| رقم الانضمام: | edsbas.A8B0E9DC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.autrev.2023.103400 |
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