دورية أكاديمية
Mahamanalactone A, a new triterpenoid from Dysoxylum malabaricum bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy
| العنوان: | Mahamanalactone A, a new triterpenoid from Dysoxylum malabaricum bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy |
|---|---|
| المؤلفون: | Nivedita Bhardwaj, Swathilakshmi S., Nancy Tripathi, Sanjay Kumar, Uma Ranjan Lal, Ravikanth G., Santosh Kumar Guru, Shreyans K. Jain |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Genetics, Pharmacology, Biotechnology, Cancer, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Dysoxylum malabaricum, Mahamanalactone A, LC-HRMS, cycloatane triterpenoids |
| الوصف: | In this recent investigation, the focus centred on exploring the potential phytoconstituents within the bark of Dysoxylum malabaricum . A profiling strategy employing LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry) was implemented for the rapid identification of compounds from the bark extract. The crude extract underwent fractionation, resulting in the isolation of four previously known compounds ( 1–4 ) and a novel cycloartane triterpenoid named Mahamanalactone A ( 5 ). Compound 5 represents a cycloartane triterpenoid with a modified ring-A, featuring £-caprolactone fusion at positions 4 and 5, distinguishing it from other reported compounds where £-caprolactone is typically fused at positions 3 and 4. Cytotoxicity assessment revealed that the newly identified compound 5 exhibited a moderate cytotoxic profile (IC 50 29 to 78 µM) against a panel of cancer cell lines. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Mahamanalactone_A_a_new_triterpenoid_from_i_Dysoxylum_malabaricum_i_bark_a_case_study_for_rapid_identification_of_new_metabolites_via_LC-HRMS_profiling_and_database_mining_strategy/24923956Test |
| DOI: | 10.6084/m9.figshare.24923956.v1 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.24923956.v1Test https://figshare.com/articles/journal_contribution/Mahamanalactone_A_a_new_triterpenoid_from_i_Dysoxylum_malabaricum_i_bark_a_case_study_for_rapid_identification_of_new_metabolites_via_LC-HRMS_profiling_and_database_mining_strategy/24923956Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.A835424D |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.24923956.v1 |
|---|