التفاصيل البيبلوغرافية
| العنوان: |
New approaches to particle induced prompt gamma imaging |
| المؤلفون: |
Nemallapudi, Mythra Varun, Rahman, Atiq Ur, Sihotang, Vanny Marantha, Tran, Thien Cong, Lin, Hsin-Hon, Lin, Chih-Hsun, Chu, Ming-Lee, Chen, Augustine Ei-Fong, Lee, Shih-Chang |
| سنة النشر: |
2022 |
| المجموعة: |
ArXiv.org (Cornell University Library) |
| مصطلحات موضوعية: |
Physics - Instrumentation and Detectors, Physics - Medical Physics |
| الوصف: |
The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning the proton range and target composition. In order to image prompt gamma we present different approaches. The first approach is based on knife-edge collimator utilized in tandem with a compact PET type detector in order to verify proton range by measuring the depth distribution of prompt gamma relying on Compton scattered events. A second approach aims at unambiguously identifying the presence of protons in a region of interest by introducing a bio-compatible fiducial marker in the patient and measuring the characteristic prompt gamma of the marker against background material. A third approach illustrates a novel design for position sensitive gamma imaging with a millimeter level adjustable position resolution with a high detection efficiency which is a step towards 3D prompt gamma imaging, useful to better understand the target composition. Simulations of the designs were performed using GATE/Geant4 Monte Carlo framework. Experimental tests on fiducial marker were conducted at the proton facilities in INER and Chang Gung Memorial hospital. Using the knife-edge PET approach a range verification of 0.7 mm can be achieved for shifts within 1 cm near the tumor region and up to 4 mm for shifts within a 4 cm window. For the fiducial marker approach we identify 984 keV as the dominant prompt gamma and show that for the 50% relative PG intensity, the R80 position falls within a 3 mm thick 48Ti marker. Using the position sensitive gamma imaging approach we present a feasible design to achieve spatial resolution values of 2.6 mm with a detection efficiency of 5.4E-6 at 6.1 MeV and up to eight depth positions in a single run. The relative advantage of these methods and the challenges in the implementation are discussed. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
http://arxiv.org/abs/2205.00200Test |
| الإتاحة: |
http://arxiv.org/abs/2205.00200Test |
| رقم الانضمام: |
edsbas.A80EDEB5 |
| قاعدة البيانات: |
BASE |
