دورية أكاديمية
Progress towards a public chemogenomic set for protein kinases and a call for contributions
| العنوان: | Progress towards a public chemogenomic set for protein kinases and a call for contributions |
|---|---|
| المؤلفون: | Drewry, DH, Wells, CI, Andrews, DM, Angell, R, Al-Ali, H, Axtman, AD, Capuzzi, SJ, Elkins, JM, Ettmayer, P, Frederiksen, M, Gileadi, O, Gray, N, Hooper, A, Knapp, S, Laufer, S, Luecking, U, Michaelides, M, Mueller, S, Muratov, E, Denny, RA, Saikatendu, KS, Treiber, DK, Zuercher, WJ, Willson, TM |
| المصدر: | PLOS ONE , 12 (8) , Article e0181585. (2017) |
| بيانات النشر: | PUBLIC LIBRARY SCIENCE |
| سنة النشر: | 2017 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CANCER-CELLS, INHIBITOR, IDENTIFICATION, INTERROGATION, SENSITIVITY, SELECTIVITY, DEPENDENCY, TARGETS |
| الوصف: | Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10078246/1/journal.pone.0181585.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10078246Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10078246/1/journal.pone.0181585.pdfTest https://discovery.ucl.ac.uk/id/eprint/10078246Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.A7C2F70B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |