دورية أكاديمية
Real-world clinical features, health-care utilization, and economic burden in decompensated cirrhosis patients: A national database
| العنوان: | Real-world clinical features, health-care utilization, and economic burden in decompensated cirrhosis patients: A national database |
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| المساهمون: | Hankil Lee, Beom Kyung Kim, Kim, Beom Kyung |
| بيانات النشر: | Blackwell Scientific Publications |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Ascites / epidemiology, Ascites / etiology, Ascites / therapy, Financial Stress, Hemorrhage, Hepatic Encephalopathy* / epidemiology, Hepatic Encephalopathy* / etiology, Hepatic Encephalopathy* / therapy, Hepatorenal Syndrome* / epidemiology, Hepatorenal Syndrome* / etiology, Hepatorenal Syndrome* / therapy, Humans, Liver Cirrhosis / complications, Liver Cirrhosis / epidemiology, Liver Cirrhosis / therapy, Patient Acceptance of Health Care, South Korea, cost, decompensation, health care, liver cirrhosis, utilization |
| الوصف: | Background: Patients with decompensated cirrhosis are well known to experience morbidity and mortality. Aim: We assessed clinical characteristics, health-care utilization, and economic burden according to the type, number, and combination of decompensation-related complications. Methods: We used recent nationally representative sample data from 2016 to 2018, covering approximately 13% of hospitalized patients in South Korea annually. Decompensation-related complications included ascites, hepatic encephalopathy (HE), gastroesophageal variceal (GEV) bleeding, and hepatorenal syndrome (HRS). Results: Among 14 601 patients with decompensated cirrhosis, 11 201 (76.7%) experienced ≥ 1 decompensation-related complications, and approximately three-quarters underwent hospitalization. The most prevalent decompensation-related complications were ascites (54.8%), GEV bleeding (33.2%), HE (27.4%), and HRS (3.6%). Patients with GEV bleeding exhibited the highest hospitalization rate (95.7%), and patients with HE or HRS underwent hospitalization for 4 weeks/year due to decompensated cirrhosis. Hospitalization costs were 1.9 times higher in patients with HRS than in those with ascites alone ($9022 vs $4673; P < 0.01). Once patients developed decompensation-related complications, 41.3% had ≥ 2 types of decompensation-related complications. As the number of decompensation-related complications increased from 0 to ≥ 3, health-care utilization and economic burden significantly increased in a stepwise manner; patients with ascites, GEV bleeding, and HE visited medical institutions 2.2 times more (11 vs 5/year; P < 0.01) and incurred 6.4 times greater medical expenditure ($11 060 vs $1728/year; P < 0.01) than those with ascites only. Conclusion: A substantial proportion of patients had multiple decompensation-related complications and socioeconomic burdens for decompensated cirrhosis considering admission rate, hospital stay, and costs increased markedly, depending on the number of decompensation-related complications. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0815-9319 1440-1746 |
| العلاقة: | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; J01417; OAK-2022-08897; https://ir.ymlib.yonsei.ac.kr/handle/22282913/192743Test; T202205651; JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.37(11) : 2154-2163, 2022-11 |
| DOI: | 10.1111/jgh.15962 |
| الإتاحة: | https://doi.org/10.1111/jgh.15962Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/192743Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.A7A605E9 |
| قاعدة البيانات: | BASE |
| تدمد: | 08159319 14401746 |
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| DOI: | 10.1111/jgh.15962 |