التفاصيل البيبلوغرافية
| العنوان: |
Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis |
| المؤلفون: |
Albers, L, Sobotzki, C, Kuss, O, Ajslev, T, Batista, RFL, Bettiol, H, Brabin, B, Buka, SL, Cardoso, VC, Clifton, VL, Devereux, G, Gilman, SE, Grzeskowiak, LE, Heinrich, J, Hummel, S, Jacobsen, GW, Graeme Jones, Koshy, G, Morgen, CS, Oken, E, Paus, T, Pausova, Z, Rifas-Shiman, SL, Sharma, AJ, da Silva, AA, Sorensen, TI, Thiering, E, Turner, S, Vik, T, von Kries, R |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Paediatrics not elsewhere classified, No keyword provided |
| الوصف: |
Background/Objectives: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear. Subject/Methods: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex. Results: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results. Conclusions: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
102.100.100/562527; https://figshare.com/articles/journal_contribution/Maternal_smoking_during_pregnancy_and_offspring_overweight_is_there_a_dose-response_relationship_An_individual_patient_data_meta-analysis/22968002Test |
| الإتاحة: |
https://figshare.com/articles/journal_contribution/Maternal_smoking_during_pregnancy_and_offspring_overweight_is_there_a_dose-response_relationship_An_individual_patient_data_meta-analysis/22968002Test |
| حقوق: |
In Copyright |
| رقم الانضمام: |
edsbas.A79428FC |
| قاعدة البيانات: |
BASE |
