دورية أكاديمية
LFA-1 in T cell priming, differentiation, and effector functions
| العنوان: | LFA-1 in T cell priming, differentiation, and effector functions |
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| المؤلفون: | Gerard, A, AP, Cope, Kemper, C, Alon, R, Kochl, R |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2021 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells. However, it is increasingly evident that LFA-1 plays additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or antigen-presenting cells. These include roles in homotypic T cell: T cell communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we summarize briefly current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:457a20d5-1bfa-496e-ae91-0293eb99d4f2Test; https://doi.org/10.1016/j.it.2021.06.004Test |
| DOI: | 10.1016/j.it.2021.06.004 |
| الإتاحة: | https://doi.org/10.1016/j.it.2021.06.004Test https://ora.ox.ac.uk/objects/uuid:457a20d5-1bfa-496e-ae91-0293eb99d4f2Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A7535997 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.it.2021.06.004 |
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