دورية أكاديمية
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. ; : circulating DC in melanoma
| العنوان: | Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. ; : circulating DC in melanoma |
|---|---|
| المؤلفون: | Charles, Julie, Di Domizio, Jérémy, Salameire, Dimitri, Bendriss-Vermare, Nathalie, Aspord, Caroline, Muhammad, Ramzan, Lefebvre, Christine, Plumas, Joël, Leccia, Marie-Thérèse, Chaperot, Laurence |
| المساهمون: | Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire recherche et développement, EFS, Département Pluridisciplinaire de Médecine, Dermatologie, Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon, Oncogénèse et progression tumorale, Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancéropole National 2004-5 (Institut National du Cancer), Société Française de Dermatologie, Académie Nationale de Médecine |
| المصدر: | ISSN: 0022-202X. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2010 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | MESH: Adult, MESH: Aged, MESH: Melanoma, MESH: Middle Aged, MESH: Receptors, CCR10, CCR6, CCR7, CXCR3, CXCR4, MESH: Skin Neoplasms, 80 and over, MESH: Case-Control Studies, MESH: Cell Movement, MESH: Chemokine CCL20, MESH: Dendritic Cells, MESH: Female, MESH: Humans, MESH: Male, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; Dendritic cells (DCs) are central cells in the development of antitumor immune responses, but the number and function of these cells can be altered in various cancers. Whether these cells are affected during the development of melanoma is not known. We investigated the presence, phenotype, and functionality of circulating myeloid DCs (MDCs) and plasmacytoid DCs (PDCs) in newly diagnosed melanoma patients, compared to controls. The frequencies of PDCs and MDCs were equivalent in melanoma patients as compared with normal subjects. Both circulating DC subsets were immature, but on ex vivo stimulation with R848 they efficiently upregulated their expression of costimulatory molecules. We found that circulating DCs from melanoma patients and controls displayed similar pattern of expression of the chemokine receptors CXCR3, CXCR4, CCR7, and CCR10. Strikingly, PDCs from melanoma patients expressed higher levels of CCR6 than control PDCs, and were able to migrate toward CCL20. Further data showed that CCR6-expressing PDCs were present in melanoma primary lesions, and that CCL20 was produced in melanoma tumors. These results suggest that PDCs and MDCs are functional in melanoma patients at the time of diagnosis, and that CCL20 may participate to their recruitment from the blood to the tumor. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/20220766; inserm-00633157; https://inserm.hal.science/inserm-00633157Test; PUBMED: 20220766 |
| DOI: | 10.1038/jid.2010.24 |
| الإتاحة: | https://doi.org/10.1038/jid.2010.24Test https://inserm.hal.science/inserm-00633157Test |
| رقم الانضمام: | edsbas.A73BBD57 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/jid.2010.24 |
|---|