دورية أكاديمية
Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.
| العنوان: | Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network. |
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| المؤلفون: | Demetri, GD, Antonescu, CR, Bjerkehagen, B, Bovée, JVMG, Boye, K, Chacón, M, Dei Tos, AP, Desai, J, Fletcher, JA, Gelderblom, H, George, S, Gronchi, A, Haas, RL, Hindi, N, Hohenberger, P, Joensuu, H, Jones, RL, Judson, I, Kang, Y-K, Kawai, A, Lazar, AJ, Le Cesne, A, Maestro, R, Maki, RG, Martín, J, Patel, S, Penault-Llorca, F, Premanand Raut, C, Rutkowski, P, Safwat, A, Sbaraglia, M, Schaefer, I-M, Shen, L, Serrano, C, Schöffski, P, Stacchiotti, S, Sundby Hall, K, Tap, WD, Thomas, DM, Trent, J, Valverde, C, van der Graaf, WTA, von Mehren, M, Wagner, A, Wardelmann, E, Naito, Y, Zalcberg, J, Blay, J-Y |
| المساهمون: | Judson, Ian |
| سنة النشر: | 2021 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Sarcoma, Receptor, trkA, Tropomyosin, Oncogene Proteins, Fusion, Protein Kinase Inhibitors, Gene Fusion, Adult |
| الوصف: | Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; 1517; application/pdf |
| اللغة: | English |
| تدمد: | 0923-7534 1569-8041 |
| العلاقة: | Annals of oncology : official journal of the European Society for Medical Oncology, 2020, 31 (11), pp. 1506 - 1517; https://repository.icr.ac.uk/handle/internal/4282Test |
| DOI: | 10.1016/j.annonc.2020.08.2232 |
| الإتاحة: | https://doi.org/10.1016/j.annonc.2020.08.2232Test https://repository.icr.ac.uk/handle/internal/4282Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.A6C99610 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09237534 15698041 |
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| DOI: | 10.1016/j.annonc.2020.08.2232 |