دورية أكاديمية
The efficacy of GLP-1RAs for the management of postprandial hypoglycemia following bariatric surgery:a systematic review
| العنوان: | The efficacy of GLP-1RAs for the management of postprandial hypoglycemia following bariatric surgery:a systematic review |
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| المؤلفون: | Llewelyn, David, Ellis, Hugh, Aylwin , Simon, Ostarijas, Eduard, Green, Shauna, Sheridan, William, Chew, Nicholas WS, le Roux, Carel W, Miras, Alexander D, Patel, Ameet G, Vincent, Royce, Dimitriadis, Georgios K |
| المصدر: | Llewelyn , D , Ellis , H , Aylwin , S , Ostarijas , E , Green , S , Sheridan , W , Chew , N WS , le Roux , C W , Miras , A D , Patel , A G , Vincent , R & Dimitriadis , G K 2023 , ' The efficacy of GLP-1RAs for the management of postprandial hypoglycemia following bariatric surgery : a systematic review ' , Obesity , vol. 31 , no. 1 , pp. 20-30 . https://doi.org/10.1002/oby.23600Test |
| سنة النشر: | 2023 |
| المجموعة: | King's College, London: Research Portal |
| الوصف: | Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux-en-Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon-like peptide-1 (GLP-1), which has an exaggerated rise following ingestion of carbohydrates after bariatric surgery. This paper sought to assess the role of GLP-1 receptor agonists (GLP-1RAs) in managing postprandial hypoglycemia following bariatric surgery. Methods MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Scopus were systematically and critically appraised for all peer-reviewed publications that suitably fulfilled the inclusion criteria established a priori. This systematic review was developed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P). It followed methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions and is registered with PROSPERO (International Prospective Register of Systematic Reviews; identifier CRD420212716429). Results and Conclusions Postprandial hyperinsulinemic hypoglycemia remains a notoriously difficult to manage metabolic complication of bariatric surgery. This first, to the authors' knowledge, systematic review presents evidence suggesting that use of GLP-1RAs does not lead to an increase of hypoglycemic episodes, and, although this approach may appear counterintuitive, the findings suggest that GLP-1RAs could reduce the number of postprandial hypoglycemic episodes and improve glycemic variability. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/oby.23600 |
| الإتاحة: | https://doi.org/10.1002/oby.23600Test https://kclpure.kcl.ac.uk/portal/en/publications/439b391d-7739-420e-833a-724d3bf7b984Test http://www.scopus.com/inward/record.url?scp=85144079137&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A6846B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/oby.23600 |
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