دورية أكاديمية
Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort
| العنوان: | Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort |
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| المؤلفون: | Grinda, T., Antoine, A., Jacot, W., Blaye, C., Cottu, P. H., Diéras, V., Dalenc, F., Goncalves, A., Debled, M., Patsouris, A., Mouret-Reynier, M. A., Mailliez, A., Clatot, F., Levy, C., Ferrero, J. M., Desmoulins, I., Uwer, L., Petit, T., Jouannaud, C., Lacroix-Triki, M., Deluche, E., Robain, M., Courtinard, Coralie, Bachelot, T., Brain, E., Perol, D., Delaloge, S. |
| المساهمون: | Institut Gustave Roussy (IGR), Centre Léon Bérard Lyon, Institut régional de Cancérologie de Montpellier (ICM), Institut Bergonié Bordeaux, UNICANCER, Institut Curie Paris, CRLCC Eugène Marquis (CRLCC), Institut Claudius Regaud, Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), Centre Jean Perrin Clermont-Ferrand (UNICANCER/CJP), Centre Régional de Lutte contre le Cancer Oscar Lambret Lille (UNICANCER/Lille), Université de Lille-UNICANCER, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Centre Régional de Lutte contre le Cancer François Baclesse Caen (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre de Lutte contre le Cancer Antoine Lacassagne Nice (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UniCA), Institut de Cancérologie de Lorraine - Alexis Vautrin Nancy (UNICANCER/ICL), Centre Paul Strauss (CRLCC Paul Strauss), Institut Jean Godinot Reims, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de médecine oncologique Gustave Roussy |
| المصدر: | ISSN: 2059-7029 ; ESMO Open ; https://hal.science/hal-03273275Test ; ESMO Open, 2021, 6 (3), pp.100114. ⟨10.1016/j.esmoop.2021.100114⟩. |
| بيانات النشر: | HAL CCSD European Society for Medical Oncology |
| سنة النشر: | 2021 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | Metastatic breast cancer, Real-life, Overall survival, HER2, New drugs, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; BACKGROUND: Treatment strategies for metastatic breast cancer (MBC) have made great strides over the past 10 years. Real-world data allow us to evaluate the actual benefit of new treatments. ESME (Epidemio-Strategy-Medico-Economical)-MBC, a nationwide observational cohort (NCT03275311), gathers data of all consecutive MBC patients who initiated their treatment in 18 French Cancer Centres since 2008.PATIENTS AND METHODS: We evaluated overall survival (OS) in the whole cohort (N = 20 446) and among subtypes: hormone receptor positive, human epidermal growth factor 2 negative (HR+/HER2-; N = 13 590), HER2+ (N = 3919), and triple-negative breast cancer (TNBC; N = 2937). We performed multivariable analyses including year of MBC diagnosis as one of the covariates, to assess the potential OS improvement over time, and we described exposure to newly released drugs at any time during MBC history by year of diagnosis (YOD).RESULTS: The median follow-up of the whole cohort was 65.5 months (95% CI 64.6-66.7). Year of metastatic diagnosis appears as a strong independent prognostic factor for OS [Year 2016 HR 0.89 (95% CI 0.82-0.97); P = 0.009, using 2008 as reference]. This effect is driven by the HER2+ subcohort, where it is dramatic [Year 2016 HR 0.52 (95% CI 0.42-0.66); P < 0.001, using 2008 as reference]. YOD had, however, no sustained impact on OS among patients with TNBC [Year 2016 HR 0.93 (95% CI 0.77-1.11); P = 0.41, using 2008 as reference] nor among those with HR+/HER2- MBC [Year 2016 HR 1.02 (95% CI 0.91-1.13); P = 0.41, using 2008 as reference]. While exposure to newly released anti-HER2 therapies appeared very high (e.g. >70% of patients received pertuzumab from 2016 onwards), use of everolimus or eribulin was recorded in less than one-third of HR+/HER2- and TNBC cohorts, respectively, whatever YOD.CONCLUSION: OS has dramatically improved among HER2+ MBC patients, probably in association with the release of several major HER2-directed therapies, whose penetrance was high. This ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03273275; https://hal.science/hal-03273275Test; https://hal.science/hal-03273275/documentTest; https://hal.science/hal-03273275/file/BPH_ESMOO_2021_Grinda.pdfTest |
| DOI: | 10.1016/j.esmoop.2021.100114 |
| الإتاحة: | https://doi.org/10.1016/j.esmoop.2021.100114Test https://hal.science/hal-03273275Test https://hal.science/hal-03273275/documentTest https://hal.science/hal-03273275/file/BPH_ESMOO_2021_Grinda.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A6793D12 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.esmoop.2021.100114 |
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