رسالة جامعية
Cerebrovascular disease associated with antiphospholipid antibodies: more questions than answers
| العنوان: | Cerebrovascular disease associated with antiphospholipid antibodies: more questions than answers |
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| المؤلفون: | Gatenby, Paul, Danta, Gytis, Tuck, Roger, Andrews, Colin, Hawkins, Carolyn |
| المصدر: | Journal of Autoimmune Diseases ; http://www.jautoimdis.com/content/pdf/1740-2557-3-3.pdfTest ; http://www.jautoimdis.com/content/3/1/3Test |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2006 |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: acetylsalicylic acid, beta2 glycoprotein 1 antibody, cardiolipin antibody, clopidogrel, immunoglobulin G antibody, immunoglobulin M antibody, lupus anticoagulant, oral contraceptive agent, phospholipid antibody, ticlopidine, warfarin, adolescent, adult |
| الوصف: | Neurological syndromes occur in a significant number of patients with antiphospholipid antibodies. The optimal management for these patients however remains uncertain. Our study is a descriptive analysis looking retrospectively at 45 patients who presented to the principal tertiary referral centre in the Australian Capital Territory, with either cerebral arterial or venous thrombosis for which there was no obvious cause for their presentation when initially reviewed. The diagnosis was based on the clinical findings made by one of three neurologists attached to our centre. Radiological findings and the presence of either IgM or IgG anticardiolipin antibodies, IgG anti-beta-2 glycoprotein 1 antibodies or a lupus anticoagulant were then documented. In this group of patients three subgroups were identified: 1. Individuals that fulfilled the Sapporo Classification Criteria 2. Individuals with transiently positive antiphospholipid antibodies and 3. Individuals with persistently low positive antiphospholipid antibodies. The most interesting of these three groups are those individuals with transiently positive antiphospholipid antibodies. A potential cause for presentation was identified in only one patient of this group with documented infective endocarditis and bacteraemia. Comparison with the other two groups suggested that there was little in terms of clinical presentation, radiological findings or intercurrent risk factors for thrombotic disease to distinguish between them. With disappearance of antiphospholipid antibodies, the individuals within this group have not had further thrombotic events. Our observations emphasise the problems that continue to exist in relation to the occurrence of cerebrovascular disease in the context of antiphospholipid antibodies and the optimal management of these stratified groups. Our findings also raise an as yet unanswered question as to the signficance of these transiently positive antiphospholipid antibodies. In the absence of significant intercurrent risk factors our findings ... |
| نوع الوثيقة: | master thesis |
| وصف الملف: | 7 pages |
| اللغة: | English |
| تدمد: | 1740-2557 |
| العلاقة: | Journal of Autoimmune Diseases 3.3 (2006); http://hdl.handle.net/10440/104Test; http://digitalcollections.anu.edu.au/handle/10440/104Test; https://openresearch-repository.anu.edu.au/bitstream/10440/104/3/Hawkins_Cerebrovascular2006.pdf.jpgTest |
| DOI: | 10.1186/1740-2557-3-3 |
| الإتاحة: | https://doi.org/10.1186/1740-2557-3-3Test http://hdl.handle.net/10440/104Test http://digitalcollections.anu.edu.au/handle/10440/104Test https://openresearch-repository.anu.edu.au/bitstream/10440/104/3/Hawkins_Cerebrovascular2006.pdf.jpgTest |
| حقوق: | http://www.sherpa.ac.uk/romeo/search.phpTest "Author can archive pre-print (ie pre-refereeing) …[and] post-print (ie final draft post-refereeing) … [and] publisher's version/PDF" - from SHERPA/RoMEO site (as at 22/02/10) ; Author retains copyright |
| رقم الانضمام: | edsbas.A658D265 |
| قاعدة البيانات: | BASE |
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| تدمد: | 17402557 |
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| DOI: | 10.1186/1740-2557-3-3 |