دورية أكاديمية
Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe
| العنوان: | Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe |
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| المؤلفون: | Del Favero, Simone, Boscari, Federico, Messori, Mirko, Rabbone, Ivana, Bonfanti, Riccardo, Sabbion, Alberto, Iafusco, Dario, Schiaffini, Riccardo, Visentin, Roberto, Calore, Roberta, Moncada, Yenny Leal, Galasso, Silvia, Galderisi, Alfonso, Vallone, Valeria, Di Palma, Federico, Losiouk, Eleonora, Lanzola, Giordano, Tinti, Davide, Rigamonti, Andrea, Marigliano, Marco, Zanfardino, Angela, Rapini, Novella, Avogaro, Angelo, Chernavvsky, Daniel, Magni, Lalo, Cobelli, Claudio, Bruttomesso, Daniela |
| المساهمون: | Del Favero, Simone, Boscari, Federico, Messori, Mirko, Rabbone, Ivana, Bonfanti, Riccardo, Sabbion, Alberto, Iafusco, Dario, Schiaffini, Riccardo, Visentin, Roberto, Calore, Roberta, Moncada, Yenny Leal, Galasso, Silvia, Galderisi, Alfonso, Vallone, Valeria, Di Palma, Federico, Losiouk, Eleonora, Lanzola, Giordano, Tinti, Davide, Rigamonti, Andrea, Marigliano, Marco, Zanfardino, Angela, Rapini, Novella, Avogaro, Angelo, Chernavvsky, Daniel, Magni, Lalo, Cobelli, Claudio, Bruttomesso, Daniela |
| سنة النشر: | 2016 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | Algorithms, Blood Glucose, Child, Preschool, Cross-Over Studies, Diabetes Mellitus, Type 1, Feasibility Studies, Female, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Pancreas, Artificial |
| الوصف: | OBJECTIVEThe Pediatric Artificial Pancreas (PedArPan) project tested a children-specific version of the modular model predictive control (MMPC) algorithm in 5-to 9-year-old children during a camp.RESEARCH DESIGN AND METHODSA total of 30 children, 5-to 9-years old, with type 1 diabetes completed an outpatient, open-label, randomized, crossover trial. Three days with an artificial pancreas (AP) were compared with three days of parent-managed sensor-augmented pump (SAP).RESULTSOvernight time-in-hypoglycemia was reduced with the AP versus SAP, median (25th-75th percentiles): 0.0% (0.0-2.2) vs. 2.2% (0.0-12.3) (P = 0.002), without a significant change of time-in-target, mean: 56.0% (SD 22.5) vs. 59.7% (21.2) (P = 0.430), but with increased mean glucose 173 mg/dL (36) vs. 150 mg/dL (39) (P = 0.002). Overall, the AP granted a threefold reduction of time-in-hypoglycemia (P < 0.001) at the cost of decreased time-in-target, 56.8% (13.5) vs. 63.1% (11.0) (P = 0.022) and increased mean glucose 169 mg/dL (23) vs. 147 mg/dL (23) (P < 0.001).CONCLUSIONSThis trial, the first outpatient single-hormone AP trial in a population of this age, shows feasibility and safety of MMPC in young children. Algorithm retuning will be performed to improve efficacy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27208335; info:eu-repo/semantics/altIdentifier/wos/WOS:000381416500026; volume:39; issue:7; firstpage:1180; lastpage:1185; numberofpages:6; journal:DIABETES CARE; http://hdl.handle.net/11562/1029728Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84992229896 |
| DOI: | 10.2337/dc15-2815 |
| الإتاحة: | https://doi.org/10.2337/dc15-2815Test http://hdl.handle.net/11562/1029728Test |
| رقم الانضمام: | edsbas.A5DB25F |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/dc15-2815 |
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