دورية أكاديمية
Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium ; Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium: Alcohol and smoking and breast cancer risk for BRCA carriers
| العنوان: | Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium ; Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium: Alcohol and smoking and breast cancer risk for BRCA carriers |
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| المؤلفون: | Terry, Mary Beth, Noguès, Catherine, Barrowdale, Daniel, Frost, Debra, Brewer, Carole, Evans, D. Gareth, Izatt, Louise, Side, Lucy, Walker, Lisa, Tischkowitz, Marc, Rogers, Mark, Porteous, Mary, Meijers-Heijboer, Hanne E.J., Gille, Johan Jp, Blok, Marinus, Hoogerbrugge, Nicoline, Daly, Mary, B., Andrulis, Irene, Buys, Saundra, John, Esther, M., Mclachlan, Sue-Anne, Friedlander, Michael, Tan, Yen, Osorio, Ana, Caldés, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-José, Arver, Brita, Olsson, Håkan, Schmutzler, Rita, Hopper, John, Milne, Roger, L, Easton, Douglas, van Leeuwen, Flora, E., Rookus, Matti, A., Andrieu, Nadine, N., Goldgar, David, E. |
| المساهمون: | Huntsman Cancer Institute Salt Lake City, University of Utah, CRLCC René Huguenin (CRLCC René Huguenin), Hôpital René Huguenin Saint-Cloud, Institut Curie - Saint Cloud (ICSC)-Institut Curie - Saint Cloud (ICSC)-UNICANCER, Centre for Cancer Genetic Epidemiology, University of Cambridge UK (CAM), Department of Clinical Genetics, Royal Devon & Exeter Hospital, Genetic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre, University of Manchester, Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, Department of Clinical Genetics, The Churchill, Oxford, Oxford Regional Genetics Service Oxford, UK, Churchill Hospital Oxford Centre for Haematology, Department of Genetics, Portuguese Oncology Institute, Department of Computer Science Colorado State University, Colorado State University Fort Collins (CSU), West General Hospital, VU University Medical Center Amsterdam, University Hospital Maastricht, Department of Human Genetics, Radboud University Medical Center Nijmegen, Division of Population Science, Fox Chase Cancer Center, Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Internal Medicine, Huntsman Cancer Institute, Department of Epidemiology, Cancer Prevention Institute of California, St. Vincent's Hospital, Sydney, Dept of Medical Oncology, Division of Medicine, University of New South Wales Sydney (UNSW)-Prince of Wales Hospital Randwick, Medizinische Universität Wien = Medical University of Vienna, Human Genetics Group, Spanish National Cancer Research Centre, Molecular Oncology Laboratory, Hospital Clínico San Carlos, Department of Genetics and Pathology, International Hereditary Cancer Centre-Pomeranian Medical University Szczecin (PUM), Laboratoire de Génomique des Cancers, Université Laval Québec (ULaval), Division of Special Gynecology, Medizinische Universität Wien = Medical University of Vienna-Department of OB/GYN, National Institute of Oncology, Masaryk Memorial Cancer Institute (MMCI), Odense University Hospital, Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Radiumhemmet, Karolinska University Hospital Stockholm, Department of Oncology, Skane University Hospital Lund, Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Clinical Center Un, Centre for MEGA Epidemiology, The University of Melbourne, Victoria, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Centre for Cancer Genetic Epidemiology Cambridge, University of Cambridge UK (CAM)-Department of Oncology, Departments of Epidemiology and Molecular Pathology, The Netherlands Cancer Institute, Netherlands Cancer Institute, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie Paris, Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris Sciences et Lettres (PSL), Department of Dermatology Salt Lake City, UT, USA, School of Medicine University of Utah, Salt Lake City, University of Utah-University of Utah, This work was supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia (809195, 1100868), the Australian National Breast Cancer Foundation (IF 17), the National Health and Medical Research Council (454508, 288704, 145684), the National Institute of Health U.S.A. (1RO1CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. Kelly Phillips is an Australian National Breast Cancer Foundation fellow.Lenka Foretova was supported by MH CZ - DRO (MMCI, 00209805) and by MEYS - NPS I- LO1413 to LF, MN. Edith Olah and The Hungarian Breast and Ovarian Cancer Study was supported by Hungarian Research Grants KTIA-OTKA CK-80745, NKFI OTKA K-112228 and the Norwegian EEA Financial Mechanism HU0115/NA/2008-3/ÖP-9. Hakan Olsson and Lund-BRCA collaborators are supported by the Swedish Cancer Society, Lund Hospital Funds, and European Research Council Advanced Grant ERC-2011-294576. Stockholm-BRCA collaborators are supported by the Swedish Cancer Society. |
| المصدر: | ISSN: 1055-9965. |
| بيانات النشر: | HAL CCSD American Association for Cancer Research |
| سنة النشر: | 2019 |
| المجموعة: | MINES ParisTech: Archive ouverte / Open Archive (HAL) |
| مصطلحات موضوعية: | BRCA1, BRCA2, breast cancer, cigarette smoking, alcohol, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; BACKGROUND:Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential.METHODS:Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS:For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk.CONCLUSIONS:The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.IMPACT:This is the largest prospective study of BRCA mutation carriers to assess these important risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31792088; inserm-02438388; https://inserm.hal.science/inserm-02438388Test; https://inserm.hal.science/inserm-02438388/documentTest; https://inserm.hal.science/inserm-02438388/file/1055-9965.EPI-19-0546.full.pdfTest; PUBMED: 31792088 |
| DOI: | 10.1158/1055-9965.EPI-19-0546 |
| الإتاحة: | https://doi.org/10.1158/1055-9965.EPI-19-0546Test https://inserm.hal.science/inserm-02438388Test https://inserm.hal.science/inserm-02438388/documentTest https://inserm.hal.science/inserm-02438388/file/1055-9965.EPI-19-0546.full.pdfTest |
| رقم الانضمام: | edsbas.A5AC299F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/1055-9965.EPI-19-0546 |
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