دورية أكاديمية
dbHiMo : a web-based epigenomics platform for histone-modifying enzymes
| العنوان: | dbHiMo : a web-based epigenomics platform for histone-modifying enzymes |
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| المؤلفون: | Choi, Jaeyoung, Kim, Ki-Tae, Huh, Aram, Kwon, Seomun, Hong, Changyoung, Asiegbu, Fred O., Jeon, Junhyun, Lee, Yong-Hwan |
| المساهمون: | Department of Forest Sciences, Frederick Asiegbu / Principal Investigator, Viikki Plant Science Centre (ViPS), Forest Ecology and Management |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2017 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | CHROMATIN, GENOME, YEAST, GCN5, SEQUENCE, COMPACTION, PHYLOGENY, CROSSTALK, EVOLUTION, PROTEINS, 1181 Ecology, evolutionary biology, 1184 Genetics, developmental biology, physiology |
| الوصف: | Over the past two decades, epigenetics has evolved into a key concept for understanding regulation of gene expression. Among many epigenetic mechanisms, covalent modifications such as acetylation and methylation of lysine residues on core histones emerged as a major mechanism in epigenetic regulation. Here, we present the database for histone-modifying enzymes (dbHiMo; http://hme.riceblast.snu.ac.krTest/) aimed at facilitating functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were identified by applying a search pipeline built upon profile hidden Markov model (HMM) to proteomes. The database incorporates 11 576 HMEs identified from 603 proteomes including 483 fungal, 32 plants and 51 metazoan species. The dbHiMo provides users with web-based personalized data browsing and analysis tools, supporting comparative and evolutionary genomics. With comprehensive data entries and associated web-based tools, our database will be a valuable resource for future epigenetics/epigenomics studies. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-361051-2 0-00-361051-9 |
| العلاقة: | This work was supported by the National Research Foundation of Korea grant funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A2A1A10051434), the Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ011154), Rural Development Administration, Republic of Korea. This work was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A6A3A04038022).; Choi , J , Kim , K-T , Huh , A , Kwon , S , Hong , C , Asiegbu , F O , Jeon , J & Lee , Y-H 2015 , ' dbHiMo : a web-based epigenomics platform for histone-modifying enzymes ' , Database-The journal of biological databases and curation . https://doi.org/10.1093/database/bav052Test; ORCID: /0000-0003-0223-7194/work/51559884; 84943147987; 8a076832-fd25-4319-80f1-53e0d159b004; http://hdl.handle.net/10138/225084Test; 000361051900001 |
| الإتاحة: | http://hdl.handle.net/10138/225084Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A58AE1E5 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780003610512 0003610519 |
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