التفاصيل البيبلوغرافية
| العنوان: |
Human bocavirus and metapneumovirus in acute wheezing in children—Is there a link with atopy? |
| المؤلفون: |
Sobkowiak, Paulina, Mikoś, Marcin, Bręborowicz, Anna, Szczepankiewicz, Aleksandra |
| المساهمون: |
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu |
| المصدر: |
The Clinical Respiratory Journal ; volume 14, issue 12, page 1201-1207 ; ISSN 1752-6981 1752-699X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2020 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Introduction Viral respiratory tract infections are the leading cause of acute wheezing in children with a significant risk of hospital admission, risk of recurrence and subsequent asthma. Human respiratory syncytial virus (RSV) and human rhinovirus (RV) in childhood wheezing are widely studied; however, accessible PCR assays enabled diagnosis of other pathogens, including bocavirus (hBOV) and metapneumovirus (hMPV). Objectives The aim of the study was to evaluate the prevalence of respiratory viruses in children hospitalized for acute wheezing along with demographic and clinical data. Methods We enrolled 101 children, n = 50 (49.5%) with wheezy bronchitis, n = 34 (33.7%) with acute bronchiolitis and n = 17 (16.8%) with exacerbation of asthma; (median age 1.41 ± 2.84 years). Multiplex real‐time PCR assay was used for virus detection. Results One or more viruses were detected in 83.2% subjects: RSV in 44.6%, followed by RV (23.8%), hBOV and hMPV (both 11.9%); other viruses were less frequent (<8%). Viral coinfection was found in 38 (37.6%) of children. ANCOVA analysis revealed significantly higher total IgE concentrations in the hMPV‐positive subgroup compared to RSV (34 kU/L vs 12.7 kU/L; P = .009) and RV (13.3 kU/L, P = .022). For both hMPV and hBOV an association with atopic dermatitis (AD) was observed: aOR for hMPV and AD was 5.6 (95%CI: 1.4‐22.7; P = .016) and 4.7 for hBOV and AD (95%CI: 1.3‐18; P = .024). Conclusion Viral detection ratio in wheezy respiratory tract infections in Polish children is high (83.2%), with both hBOV and hMPV at 11.9% The results also suggest possible relationship of hBOV wheezy infection with nonspecific markers of atopy in children. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/crj.13261 |
| الإتاحة: |
https://doi.org/10.1111/crj.13261Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.A49F64C7 |
| قاعدة البيانات: |
BASE |
