دورية أكاديمية
Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours:a multicentre retrospective observational cohort study
| العنوان: | Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours:a multicentre retrospective observational cohort study |
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| المؤلفون: | Osterlund, P., Kinos, S., Pfeiffer, P., Salminen, T., Kwakman, J. J.M., Frödin, J. E., Shah, C. H., Sorbye, H., Ristamäki, R., Halonen, P., Soveri, L. M., Heervä, E., Ålgars, A., Bärlund, M., Hagman, H., McDermott, R., O'Reilly, M., Röckert, R., Liposits, G., Kallio, R., Flygare, P., Teske, A. J., van Werkhoven, E., Punt, C. J.A., Glimelius, B. |
| المصدر: | Osterlund , P , Kinos , S , Pfeiffer , P , Salminen , T , Kwakman , J J M , Frödin , J E , Shah , C H , Sorbye , H , Ristamäki , R , Halonen , P , Soveri , L M , Heervä , E , Ålgars , A , Bärlund , M , Hagman , H , McDermott , R , O'Reilly , M , Röckert , R , Liposits , G , Kallio , R , Flygare , P , Teske , A J , van Werkhoven , E , .... |
| سنة النشر: | 2022 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | S-1, cardiac toxicity, cardiotoxicity, colorectal cancer, fluoropyrimidines, gastrointestinal cancer, Capecitabine/adverse effects, Humans, Middle Aged, Neoplasms/drug therapy, Male, Young Adult, Cardiotoxicity/etiology, Fluorouracil/adverse effects, Aged, 80 and over, Adult, Female, Retrospective Studies |
| الوصف: | Background: Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence regarding the safety of switching to S-1 after 5-FU- or capecitabine-associated cardiotoxicity is scarce. Patients and methods: This retrospective study (NCT04260269) was conducted at 13 centres in 6 countries. The primary endpoint was recurrence of cardiotoxicity after switch to S-1-based treatment due to 5-FU- or capecitabine-related cardiotoxicity: clinically meaningful if the upper boundary of the 95% confidence interval (CI; by competing risk) is not including 15%. Secondary endpoints included cardiac risk factors, diagnostic work-up, treatments, outcomes, and timelines of cardiotoxicity. Results: Per protocol, 200 patients, treated between 2011 and 2020 [median age 66 years (range 19-86); 118 (59%) males], were included. Treatment intent was curative in 145 (73%). Initial cardiotoxicity was due to capecitabine (n = 170), continuous infusion 5-FU (n = 22), or bolus 5-FU (n = 8), which was administered in combination with other chemotherapy, targeted agents, or radiotherapy in 133 patients. Previous cardiovascular comorbidities were present in 99 (50%) patients. Cardiotoxic events (n = 228/200) included chest pain (n = 125), coronary syndrome/infarction (n = 69), arrhythmia (n = 22), heart failure/cardiomyopathy (n = 7), cardiac arrest (n = 4), and malignant hypertension (n = 1). Cardiotoxicity was severe or life-threatening in 112 (56%) patients and led to permanent capecitabine/5-FU discontinuation in 192 (96%). After switch to S-1, recurrent cardiotoxicity was observed in eight (4%) patients (95% CI 2.02-7.89, primary endpoint met). Events were limited to grade 1-2 and occurred at a median of 16 days (interquartile range 7-67) from therapy switch. Baseline ischemic heart disease was a risk factor for recurrent cardiotoxicity (odds ratio 6.18, 95% CI 1.36-28.11). Conclusion: Switching to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/96ddf7d2-7bf1-4216-905f-eac256d63f9bTest |
| DOI: | 10.1016/j.esmoop.2022.100427 |
| الإتاحة: | https://doi.org/10.1016/j.esmoop.2022.100427Test https://portal.findresearcher.sdu.dk/da/publications/96ddf7d2-7bf1-4216-905f-eac256d63f9bTest https://findresearcher.sdu.dk/ws/files/205421658/1_s2.0_S2059702922000485_main.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A457F093 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.esmoop.2022.100427 |
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