دورية أكاديمية
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
| العنوان: | Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals |
|---|---|
| المؤلفون: | Healy, Katie, Pin, Elisa, Chen, Puran, Söderdahl, Gunnar, Nowak, Piotr, Mielke, Stephan, Hansson, Lotta, Bergman, Peter, Smith, C.I. Edvard, Ljungman, Per, Valentini, Davide, Blennow, Ola, Österborg, Anders, Gabarrini, Giorgio, Al-Manei, Khaled, Alkharaan, Hassan, Sobkowiak, Michał Jacek, Yousef, Jamil, Mravinacova, Sara, Cuapio, Angelica, Xu, Xinling, Akber, Mira, Loré, Karin, Hellström, Cecilia, Muschiol, Sandra, Bogdanovic, Gordana, Buggert, Marcus, Ljunggren, Hans-Gustaf, Hober, Sophia, Nilsson, Peter, Aleman, Soo, Sällberg Chen, Margaret |
| بيانات النشر: | Umeå universitet, Molekylär Infektionsmedicin, Sverige (MIMS) Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden Division of Protein Technology, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden Cell Press |
| سنة النشر: | 2022 |
| المجموعة: | Umeå University: Publications (DiVA) |
| مصطلحات موضوعية: | antibody, cancer, COVID-19, HIV, immunodeficiency, saliva, serum, Translation to patients, transplantation, vaccination, Infectious Medicine, Infektionsmedicin |
| الوصف: | Background: Immunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown. Methods: Immunocompromised patients (n = 404) and healthy controls (n = 82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys anti-SARS-CoV-2 S assay. Findings: IgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to those of healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded area under the curve (AUC) = 0.95 and positive predictive value (PPV) = 90.7% for the entire cohort after vaccination. Conclusions: Saliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary spike IgG makes it highly suitable for screening vulnerable groups for revaccination. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | 2022, 3:2, s. 137-153.e3; Med, 2666-6359, 2022, 3:2, s. 137-153.e3; http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192375Test; PMID 35075450; ISI:000758830400012; Scopus 2-s2.0-85123922478 |
| DOI: | 10.1016/j.medj.2022.01.001 |
| الإتاحة: | https://doi.org/10.1016/j.medj.2022.01.001Test http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192375Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A45552F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.medj.2022.01.001 |
|---|