التفاصيل البيبلوغرافية
| العنوان: |
Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials |
| المؤلفون: |
Böhm, Michael, Schumacher, Helmut, Teo, Koon K., Lonn, Eva M., Mahfoud, Felix, Ukena, Christian, Mann, Johannes F. E., Mancia, Giuseppe, Redon, Josep, Schmieder, Roland E., Sliwa, Karen, Marx, Nikolaus, Weber, Michael A., Williams, Bryan, Yusuf, Salim |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
2020 |
| المجموعة: |
Australian Catholic University: ACU Research Bank |
| مصطلحات موضوعية: |
Diabetes, Cardiovascular risk, Myocardial infarction, Heart failure, Blood pressure, ONTARGET, TRANSCEND, Heart rate |
| الوصف: |
Aims Resting heart rate (RHR) has been shown to be associated with cardiovascular outcomes in various conditions. It is unknown whether different levels of RHR and different associations with cardiovascular outcomes occur in patients with or without diabetes, because the impact of autonomic neuropathy on vascular vulnerability might be stronger in diabetes. Methods and results We examined 30 937 patients aged 55 years or older with a history of or at high risk for cardiovascular disease and after myocardial infarction, stroke, or with proven peripheral vascular disease from the ONTARGET and TRANSCEND trials investigating ramipril, telmisartan, and their combination followed for a median of 56 months. We analysed the association of mean achieved RHR on-treatment with the primary composite outcome of cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure, the components of the composite primary outcome, and all-cause death as continuous and categorical variables. Data were analysed by Cox regression analysis, ANOVA, and χ2 test. These trials were registered with ClinicalTrials.gov.number NCT00153101. Patients were recruited from 733 centres in 40 countries between 1 December 2001 and 31 July 2008 (ONTARGET) and 1 November 2001 until 30 May 2004 (TRANSCEND). In total, 19 450 patients without diabetes and 11 487 patients with diabetes were stratified by mean RHR. Patients with diabetes compared to no diabetes had higher RHRs (71.8 ± 9.0 vs. 67.9 ± 8.8, P < 0.0001). In the categories of <60 bpm, 60 ≤ 65 bpm, 65 ≤ 70 bpm, 70 ≤ 75 bpm, 75 ≤ 80 bpm and ≥80 bpm, non-diabetic patients had an increased hazard of the primary outcome with mean RHR of 75 ≤ 80 bpm (adjusted hazard ratio [HR] 1.17 (1.01–1.36)) compared to RHR 60 ≤ 65 bpm. For patients with in-trial RHR ≥80 bpm the hazard ratios were highest (diabetes: 1.96 (1.64–2.34), no diabetes: 1.73 (1.49–2.00), For cardiovascular death hazards were also clearly increased at RHR ≥80 bpm (diabetes [1.99, (1.53–2.58)], no diabetes [1.73 ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| تدمد: |
0195-668X |
| العلاقة: |
https://acuresearchbank.acu.edu.au/item/855w6/resting-heart-rate-and-cardiovascular-outcomes-in-diabetic-and-non-diabetic-individuals-at-high-cardiovascular-risk-analysis-from-the-ontarget-transcend-trialsTest; https://doi.org/10.1093/eurheartj/ehy808Test; Böhm, Michael, Schumacher, Helmut, Teo, Koon K., Lonn, Eva M., Mahfoud, Felix, Ukena, Christian, Mann, Johannes F. E., Mancia, Giuseppe, Redon, Josep, Schmieder, Roland E., Sliwa, Karen, Marx, Nikolaus, Weber, Michael A., Williams, Bryan and Yusuf, Salim. (2020). Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials. European Heart Journal. 41(2), pp. 231 - 238. https://doi.org/10.1093/eurheartj/ehy808Test |
| DOI: |
10.1093/eurheartj/ehy808 |
| الإتاحة: |
https://doi.org/10.1093/eurheartj/ehy808Test |
| رقم الانضمام: |
edsbas.A44A31E5 |
| قاعدة البيانات: |
BASE |
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