التفاصيل البيبلوغرافية
| العنوان: |
Erk associates with and primes GSK-3 beta for its inactivation resulting in upregulation of beta-catenin |
| المؤلفون: |
Ding, QQ, Xia, WY, Liu, JC, Yang, JY, Lee, DF, Xia, JH, Bartholomeusz, G, Li, Y, Pan, Y, Li, Z, Bargou, RC, Qin, J, Lai, CC, Tsai, FJ, Tsai, CH, Hung, MC |
| المساهمون: |
附設醫院, Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA, Univ Texas, Grad Sch Biomed Sci, Houston, TX 77030 USA, Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Surg, Union Hosp, Wuhan 430022, Peoples R China, Humboldt Univ, Max Delbruck Ctr Mol Med, Robert Rossle Canc Clin, HELIOS Clin, D-13125 Berlin, Germany, Humboldt Univ, Max Delbruck Ctr Mol Med, Dept Hematol Oncol & Tumor Immunol, D-13125 Berlin, Germany, Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA, China Med Univ Hosp, Taichung 404, Taiwan |
| بيانات النشر: |
CELL PRESS |
| سنة النشر: |
2005 |
| المجموعة: |
China Medical University Repository, Taiwan (CMUR) / 中國醫藥大學機構典藏 |
| الوصف: |
In the present study, role of guanosine-3',5'-cyclic monophosphate (cGMP) in the vasodilatation of tetramethylpyrazine (TMP), one of the active ingredients of the Chinese herb Chuang-xion, was investigated. We found that the TMP could decrease the vascular tone of isolated rat aorta precontracted with phenylephrine (10(-8) M) in a concentration-dependent manner from 10(-5) M to 10(-3) M. Also, the TMP-induced relaxation was reduced by 1H-(1,2,4)-oxadiazol-(4,3-a)-quinoxalin-1-one (ODQ) or methylene blue, the inhibitor of soluble guanylyl cyclase. Moreover, the vasodilative response to TMP was enhanced significantly in the presence of sildenafil, a well-known inhibitor of phosphodiestrase type 5 that is sensitive to cGMP. In addition, TMP could increase the cGMP level in the isolated aortic rings and TMP-induced vasodilatation was deleted by cGMP-dependent protein kinases (PKG) blockade. These results suggest that relaxation of rat aortic strip by TMP is induced in the cGMP-dependent manner. (c) 2005 Elsevier Inc. All rights reserved. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
MOLECULAR CELL 19(2):159-170; http://ir.cmu.edu.tw/ir/handle/310903500/28975Test |
| الإتاحة: |
http://ir.cmu.edu.tw/ir/handle/310903500/28975Test |
| رقم الانضمام: |
edsbas.A3FAC83C |
| قاعدة البيانات: |
BASE |
