دورية أكاديمية
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion
| العنوان: | The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion |
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| المؤلفون: | Padilla-Rodriguez, Marco, Parker, Sara S., Adams, Deanna G., Westerling, Thomas, Puleo, Julieann I., Watson, Adam W., Hill, Samantha M., Noon, Muhammad, Gaudin, Raphael, Aaron, Jesse, Tong, Daoqin, Roe, Denise J., Knudsen, Beatrice, Mouneimne, Ghassan |
| المساهمون: | Univ Arizona, BioComp Facil, Univ Arizona, Coll Social & Behav Sci, Sch Geog & Dev, Univ Arizona, Ctr Canc, Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth |
| المصدر: | Nature Communications ; 9 ; 1 |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2018 |
| المجموعة: | The University of Arizona: UA Campus Repository |
| الوصف: | Estrogen promotes growth of estrogen receptor-positive (ER+) breast tumors. However, epidemiological studies examining the prognostic characteristics of breast cancer in postmenopausal women receiving hormone replacement therapy reveal a significant decrease in tumor dissemination, suggesting that estrogen has potential protective effects against cancer cell invasion. Here, we show that estrogen suppresses invasion of ER+ breast cancer cells by increasing transcription of the Ena/VASP protein, EVL, which promotes the generation of suppressive cortical actin bundles that inhibit motility dynamics, and is crucial for the ERmediated suppression of invasion in vitro and in vivo. Interestingly, despite its benefits in suppressing tumor growth, anti-estrogenic endocrine therapy decreases EVL expression and increases local invasion in patients. Our results highlight the dichotomous effects of estrogen on tumor progression and suggest that, in contrast to its established role in promoting growth of ER+ tumors, estrogen has a significant role in suppressing invasion through actin cytoskeletal remodeling. ; Gordon and Betty Moore Foundation; Howard Hughes Medical Institute; NCI grant [RO1 CA196885-01]; Science Foundation Arizona Bisgrove Scholars Postdoctoral Fellowship; NCI University of Arizona Cancer Center Support Grant [P30CA023074] ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | http://www.nature.com/articles/s41467-018-05367-2Test; Padilla-Rodriguez, M., Parker, S. S., Adams, D. G., Westerling, T., Puleo, J. I., Watson, A. W., . Mouneimne, G. (2018). The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nature Communications, 9(1), [2980]. https://doi.org/10.1038/s41467-018-05367-2Test; http://hdl.handle.net/10150/631111Test; NATURE COMMUNICATIONS |
| DOI: | 10.1038/s41467-018-05367-2 |
| الإتاحة: | https://doi.org/10.1038/s41467-018-05367-2Test http://hdl.handle.net/10150/631111Test |
| حقوق: | © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.A3D8774B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-018-05367-2 |