دورية أكاديمية
Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia
| العنوان: | Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia |
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| المؤلفون: | Nuzzo, Alexandre, Guedj, Kevin, Curac, Sonja, Hercend, Claude, Bendavid, Claude, Gault, Nathalie, Tran-Dinh, Alexy, Ronot, Maxime, Nicoletti, Antonino, Bouhnik, Yoram, Castier, Yves, Corcos, Olivier, Peoc’h, Katell |
| المساهمون: | Hôpital Beaujon AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'investigation Clinique CHU Bichat - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Grants from MSD-Avenir and APHP funded the SURVIBIO study, Alexandre Nuzzo received Ph.D. Grants from “Fondation de l'Avenir” and the French Gastroenterology Society (SNFGE)., SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center): Audrey Huguet, Carmen Stefanescu, Xavier Treton, Francisca Joly, Lore Billiauws, Annick Hamon, Aureline Boitet, Céline Lekhal, David Deutsch, Elsa Oiknin, Laura Cohen, Gabriel Marcellier, Jean Senemaud, Felix Corre, Damien Soudan, Cosmin Voican, Jean-Baptiste Leclère, Jules Iquilles, Lucas Raynaud, Luisa Paulatto, Manon Haas, Mathieu Uzzan, Mathilde Cohen, Sara Tadbiri, Servane Prevot, Yves Panis, Alice Frontali, Simon Msika, Lara Ribeiro, Lionel Rebibo, Konstantinos Arapis, Marion Orville, Annie Sibert, Pauline Copin, Magaly Zappa, Marco Dioguardi Burgio, Valérie Vilgrain, Caroline Bertin, Anne Kerbaol, Wassim Allaham, Quentin Pellenc, Arnaud Roussel, Pierre Cerceau, Iannis Ben Abdallah, Antoine Girault, Pierre Mordant, Romain De Blic, Catherine Paugam, Emmanuel Weiss, Paer-Selim Abback, Isabelle Enriquez, Sylvie Janny, Helene Bout, Mikhael Giabicani, Marina Achouf, Bénédicte Grigoresco, Linda Koy Ear, Sonja Curac, Agnès Cachier, Aurelie Plessier, Pierre-Emmanuel Rautou, Dominique Valla, Audrey Payancé, Alain Sauvanet, Safi Dokmak, Federica Dondero, Ailton Sepulveda, Olivier Farges, Beatrice Aussilhou, Bénédicte Jais, Dominique Cazals-Hatem, Emmanuelle De Raucourt, Larbi Boudaoud, Catherine Trichet, Herve Puy, Nathalie Pons-Kerjean, Jeanick Stocco, Julie Bataille, Valérie Bouton, Philippe Montravers, Pascal Augustin, Brice Lortat Jacob, Jean-Baptiste Michel, Dominique Gauguier, Marc-Emmanuel Dumas, François Brial, Antonis Myridakis, Laura Martinez-Gili, Michael Olanipekun, Estelle Marcault, Cindie Nilusmas, Anne Barnier, Aminata Souare |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI-citrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients-50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0-26.0) vs. 23.3 μmol/L (18.3-29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58-0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34556697; hal-03369677; https://hal.science/hal-03369677Test; https://hal.science/hal-03369677/documentTest; https://hal.science/hal-03369677/file/s41598-021-98012-w.pdfTest; PUBMED: 34556697; WOS: 000698791600100 |
| DOI: | 10.1038/s41598-021-98012-w |
| الإتاحة: | https://doi.org/10.1038/s41598-021-98012-wTest https://hal.science/hal-03369677Test https://hal.science/hal-03369677/documentTest https://hal.science/hal-03369677/file/s41598-021-98012-w.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A3AD335B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-98012-w |
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