التفاصيل البيبلوغرافية
| العنوان: |
Quality of Life in Children With Crohn Disease |
| المؤلفون: |
Hill, RJ, Lewindon, PJ, Muir, R, Grangé, I, Connor, FL, Ee, LC, Withers, GD, Cleghorn, GJ, Davies, PSW |
| المصدر: |
Journal of Pediatric Gastroenterology and Nutrition ; volume 51, issue 1, page 35-40 ; ISSN 0277-2116 1536-4801 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2010 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Objectives: Quality of life (QOL) is reportedly poor in children with Crohn disease (CD) but improves with increasing disease duration. This article aims to detail QOL in a cohort of Australian children with CD in relation to disease duration, disease activity, and treatment. Materials and Methods: QOL, assessed using the IMPACT‐III questionnaire, and disease activity measures, assessed using the Pediatric Crohn's Disease Activity Index (PCDAI), were available in 41 children with CD. For this cohort, a total of 186 measurements of both parameters were available. Results: QOL was found to be significantly lower, and disease activity significantly higher ( F = 31.1, P = 0.00), in patients within 6 months of their diagnosis compared with those up to 2.5 years, up to 5 years, and beyond 5 years since diagnosis. Higher disease activity was associated with poorer QOL ( r = −0.51, P = 0.00). Total QOL was highest in children on nil medications and lowest in children on enteral nutrition. The PCDAI ( t = −6.0, P = 0.00) was a significant predictor of QOL, with the clinical history ( t = −6.9, P = 0.00) and examination ( t = −2.9, P = 0.01) sections of the PCDAI significantly predicting QOL. Disease duration, age, or sex was neither related to nor significant predictors of QOL, but height z score and type of treatment approached significance. Conclusions: Children with CD within 6 months of their diagnosis have impaired QOL compared with those diagnosed beyond 6 months. These patients, along with those with growth impairment, ongoing elevated disease activity with abdominal pain, diarrhoea and/or perirectal and extraintestinal complications, may benefit from regular assessments of QOL as part of their clinical treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/mpg.0b013e3181c2c0ef |
| DOI: |
10.1097/MPG.0b013e3181c2c0ef |
| الإتاحة: |
https://doi.org/10.1097/mpg.0b013e3181c2c0efTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.A387054F |
| قاعدة البيانات: |
BASE |
