التفاصيل البيبلوغرافية
| العنوان: |
γ‑Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor |
| المؤلفون: |
Qian Liu (135614), Jie Yuan (208425), Renfeng Jiang (14404607), Longwei He (1670674), Xuefeng Yang (603180), Lin Yuan (46306), Dan Cheng (561571) |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Cell Biology, Neuroscience, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, sensing unit linked, acute liver injury, >- carcinowa tissues, important clinical biomarker, sensitively recognize ggt, stable nir fluorophore, highly sensitive diagnosis, accurate tumor resection, γ ‑ glutamyltransferase, ggt , para <, clinical field, ggt level, ggt expression, ggt activity, tumor γ, track changes, strong turn, remedy process, related diagnosis, potential tool, photoacoustic signal, photoacoustic reporter, photoacoustic dual |
| الوصف: |
γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is closely related to many diseases. Visualizing the GGT fluctuation facilitates early disease-related diagnosis and therapy. Herein, an activated probe ( NIR-GGT ) for the imaging of GGT activity was prepared. The probe consists of a stable NIR fluorophore with the tunable amino group decorated with the γ-glutamate group as a GGT-sensing unit linked by a self-elimination group. NIR-GGT can sensitively recognize GGT and cause a strong turn-on fluorescent and photoacoustic signal. The up-regulation of the GGT expression in acetaminophen-induced acute liver injury was imaged using NIR-GGT . The probe can track changes in the GGT level in the early stages of drug-induced acute liver injury (DIALI) and its remedy process by fluorescent and photoacoustic dual-modality imaging with a high temporal–spatial resolution. NIR-GGT can also be used to differentiate between tumor and para -carcinowa tissues in vivo. The probe may be a potential tool for the diagnosis of early-stage DIALI and accurate tumor resection in the clinical field. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/_Glutamyltransferase-Activatable_Fluoro-Photoacoustic_Reporter_for_Highly_Sensitive_Diagnosis_of_Acute_Liver_Injury_and_Tumor/21879017Test |
| DOI: |
10.1021/acs.analchem.2c04894.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.analchem.2c04894.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.A3779CA4 |
| قاعدة البيانات: |
BASE |
