التفاصيل البيبلوغرافية
| العنوان: |
The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans |
| المؤلفون: |
Saul, Josh, Hirose, Takashi, Horvitz, H Robert |
| المساهمون: |
Massachusetts Institute of Technology. Department of Biology |
| المصدر: |
eLife |
| بيانات النشر: |
eLife Sciences Publications, Ltd |
| سنة النشر: |
2022 |
| المجموعة: |
DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: |
Cell identity is characterized by a distinct combination of gene expression, cell morphology, and cellular function established as progenitor cells divide and differentiate. Following establishment, cell identities can be unstable and require active and continuous maintenance throughout the remaining life of a cell. Mechanisms underlying the maintenance of cell identities are incompletely understood. Here, we show that the gene ctbp-1, which encodes the transcriptional corepressor C-terminal binding protein-1 (CTBP-1), is essential for the maintenance of the identities of the two AIA interneurons in the nematode Caenorhabditis elegans. ctbp-1 is not required for the establishment of the AIA cell fate but rather functions cell-autonomously and can act in later larval stage and adult worms to maintain proper AIA gene expression, morphology and function. From a screen for suppressors of the ctbp-1 mutant phenotype, we identified the gene egl-13, which encodes a SOX family transcription factor. We found that egl-13 regulates AIA function and aspects of AIA gene expression, but not AIA morphology. We conclude that the CTBP-1 protein maintains AIA cell identity in part by utilizing EGL-13 to repress transcriptional activity in the AIAs. More generally, we propose that transcriptional corepressors like CTBP-1 might be critical factors in the maintenance of cell identities, harnessing the DNA-binding specificity of transcription factors like EGL-13 to selectively regulate gene expression in a cell-specific manner. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
eLife; https://hdl.handle.net/1721.1/146808Test; Saul, Josh, Hirose, Takashi and Horvitz, H Robert. 2022. "The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans." eLife, 11. |
| الإتاحة: |
https://hdl.handle.net/1721.1/146808Test |
| حقوق: |
Creative Commons Attribution 4.0 International license ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A2C9BD19 |
| قاعدة البيانات: |
BASE |
