دورية أكاديمية
Black African men with early type 2 diabetes have similar muscle, liver and adipose tissue insulin sensitivity to white European men despite lower visceral fat
| العنوان: | Black African men with early type 2 diabetes have similar muscle, liver and adipose tissue insulin sensitivity to white European men despite lower visceral fat |
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| المؤلفون: | Bello, Oluwatoyosi, Mohandas, Cynthia, Shojee-Moradie, Fariba, Jackson, Nicola, Hakim, Olah, Alberti, K George M M, Peacock, Janet L, Umpleby, A Margot, Amiel, Stephanie A, Goff, Louise M |
| المصدر: | Bello , O , Mohandas , C , Shojee-Moradie , F , Jackson , N , Hakim , O , Alberti , K G M M , Peacock , J L , Umpleby , A M , Amiel , S A & Goff , L M 2019 , ' Black African men with early type 2 diabetes have similar muscle, liver and adipose tissue insulin sensitivity to white European men despite lower visceral fat ' , Diabetologia , vol. 62 , no. 5 , pp. 835-844 . https://doi.org/10.1007/s00125-019-4820-6Test |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adolescent, Adult, Africa/epidemiology, African Continental Ancestry Group, Aged, Area Under Curve, Body Composition, Diabetes Mellitus, Type 2/ethnology, European Continental Ancestry Group, Glucose Clamp Technique, Humans, Insulin/metabolism, Insulin Resistance, Intra-Abdominal Fat/metabolism, Liver/metabolism, London, Magnetic Resonance Imaging, Male, Middle Aged, Muscle, Skeletal/metabolism, Obesity/metabolism, Young Adult |
| الوصف: | AIMS/HYPOTHESIS: Type 2 diabetes is more prevalent in black African than white European populations although, paradoxically, black African individuals present with lower levels of visceral fat, which has a known association with insulin resistance. Insulin resistance occurs at a tissue-specific level; however, no study has simultaneously compared whole body, skeletal muscle, hepatic and adipose tissue insulin sensitivity between black and white men. We hypothesised that, in those with early type 2 diabetes, black (West) African men (BAM) have greater hepatic and adipose tissue insulin sensitivity, compared with white European men (WEM), because of their reduced visceral fat.METHODS: Eighteen BAM and 15 WEM with type 2 diabetes underwent a two-stage hyperinsulinaemic-euglycaemic clamp with stable glucose and glycerol isotope tracers to assess tissue-specific insulin sensitivity and a magnetic resonance imaging scan to assess body composition.RESULTS: We found no ethnic differences in whole body, skeletal muscle, hepatic or adipose tissue insulin sensitivity between BAM and WEM. This finding occurred in the presence of lower visceral fat in BAM (3.72 vs 5.68 kg [mean difference -1.96, 95% CI -3.30, 0.62]; p = 0.01). There was an association between skeletal muscle and adipose tissue insulin sensitivity in WEM that was not present in BAM (r = 0.78, p < 0.01 vs r = 0.25 p = 0.37). CONCLUSIONS/INTERPRETATION: Our data suggest that in type 2 diabetes there are no ethnic differences in whole body, skeletal muscle, hepatic and adipose tissue insulin sensitivity between black and white men, despite differences in visceral adipose tissue, and that impaired lipolysis may not be contributing to skeletal muscle insulin resistance in men of black African ethnicity. © 2021, The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1007/s00125-019-4820-6 |
| الإتاحة: | https://doi.org/10.1007/s00125-019-4820-6Test https://pure.roehampton.ac.uk/portal/en/publications/41d8c221-041f-4a3b-89fa-8b9f6194605cTest https://pure.roehampton.ac.uk/ws/files/6090786/Bello_2019_Diabetologia.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A2C52D03 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00125-019-4820-6 |
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