دورية أكاديمية
Temporal pole proton preoperative magnetic resonance spectroscopy in patients undergoing surgery for mesial temporal sclerosis
| العنوان: | Temporal pole proton preoperative magnetic resonance spectroscopy in patients undergoing surgery for mesial temporal sclerosis |
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| المؤلفون: | Fountas, K. N., Tsougos, I., Gotsis, E. D., Giannakodimos, S., Smith, J. R., Kapsalaki, E. Z. |
| المصدر: | ://WOS:000301005400004 |
| سنة النشر: | 2012 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | epilepsy, gliosis, ischemia, mesial temporal sclerosis, magnetic, resonance spectroscopy, temporal pole, NEURONAL METABOLIC DYSFUNCTION, LOBE EPILEPSY, HIPPOCAMPAL SCLEROSIS, WHITE-MATTER, H-1 MRS, HYPOMETABOLISM, NORMALIZATION, LOCALIZATION, PET, Clinical Neurology, Surgery |
| الوصف: | Object. The purpose of this prospective study was to compare the results of proton MR spectroscopy (MRS) in temporal poles in patients with unilateral mesial temporal sclerosis (MTS) with the histopathological findings of the resected temporal poles. Methods. A total of 23 patients (14 male and 9 female) with a mean age of 25.2 years (range 17-45 years) were included in this study, which was conducted over a 4-year period. All patients suffered medically refractory epilepsy due to unilateral, MRI-proven MTS, with no other imaging abnormalities. All participants underwent preoperative single-voxel proton MRS using a 3-T MRI unit. The hippocampi and temporal poles were examined bilaterally. The concentrations of N-acetyl-aspartate (NAA), choline (Cho), and creatine (Cr) were measured, and the NAA/Cho, NAA/Cr, and NAA/Cho+Cr ratios were calculated. All patients underwent anterior temporal lobectomy and ipsilateral amygdalohippocampectomy, and surgical specimens from the temporal poles were sent for histopathological examination. Comparisons of the spectroscopic and histopathological results of the resected temporal poles were performed. The modified Engel classification system was used for evaluating seizure outcome in the cohort. Results. The preoperative spectroscopic profiles of the sclerotic hippocampi were abnormal in all patients, and the contralateral hippocampus showed altered spectroscopic findings in 12 patients (52.2%). Spectroscopy of the temporal poles demonstrated severely decreased concentrations of NAA, markedly increased concentrations of Cho, and increased concentrations of Cr in the temporal pole ipsilateral to the MTS in 15 patients (65.2%). Similarly, the NAA/Cho, NAA/Cr, and NAA/Cho+Cr ratios were severely decreased in the temporal pole ipsilateral to the MTS in 16 patients (69.6%). Histopathological examination of the resected temporal poles demonstrated ischemic changes in 5 patients (21.7%), gliotic changes in 4 (17.4%), demyelinating changes in 3 (13.0%), and microdysplastic changes in 1 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1092-0684 |
| العلاقة: | http://hdl.handle.net/11615/27536Test |
| DOI: | 10.3171/2012.1.focus11327 |
| الإتاحة: | https://doi.org/10.3171/2012.1.focus11327Test http://hdl.handle.net/11615/27536Test |
| رقم الانضمام: | edsbas.A28A2193 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10920684 |
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| DOI: | 10.3171/2012.1.focus11327 |