التفاصيل البيبلوغرافية
| العنوان: |
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) |
| المؤلفون: |
Darabi, H. (Hatef), Beesley, J. (Jonathan), Droit, A. (Arnaud), Kar, S. (Siddhartha), Nord, S. (Silje), Marjaneh, M.M. (Mahdi Moradi), Soucy, P. (Penny), Michailidou, K. (Kyriaki), Ghoussaini, M. (Maya), Wahl, H.F. (Hanna Fues), Bolla, M.K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Alonso, M.R. (Rosario), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Beckmann, M.W. (Matthias), Benítez, J. (Javier), Bogdanova, N.V. (Natalia), Bojesen, S.E. (Stig), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Broeks, A. (Annegien), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Chang-Claude, J. (Jenny), Choi, J.-Y. (Ji-Yeob), Conroy, D. (Don), Couch, F.J. (Fergus), Cox, A. (Angela), Cross, S.S. (Simon), Czene, K. (Kamila), Devilee, P. (Peter), Dörk, T. (Thilo), Easton, D.F. (Douglas F.), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Fletcher, O. (Olivia), Flyger, H. (Henrik), Galle, E. (Eva), García-Closas, M. (Montserrat), Giles, G.G. (Graham G.), Goldberg, M.S. (Mark), González-Neira, A. (Anna), Guénel, P. (Pascal), Haiman, C.A. (Christopher A.), Hallberg, E. (Emily), Hamann, U. (Ute), Hartman, J.M. (Joost), Hollestelle, A. (Antoinette), Hopper, J.L. (John), Ito, H. (Hidemi), Jakubowska, A. (Anna), Johnson, N. (Nichola), Kang, D. (Daehee), Khan, S. (Sofia), Kosma, V-M. (Veli-Matti), Kriege, M. (Mieke), Kristensen, V. (Vessela), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Lee, S.C. (Soo Chin), Lindblom, A. (Annika), Lophatananon, A. (Artitaya), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Matsuo, K. (Keitaro), Mayes, R. (Rebecca), McKay, J. (James), Meindl, A. (Alfons), Milne, R.L. (Roger), Muir, K.R. (K.), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Olswold, C. (Curtis), Orr, N. (Nick), Peterlongo, P. (Paolo), Pita, G. (Guillermo), Pykäs, K. (Katri), Rudolph, A. (Anja), Sangrajrang, S. (Suleeporn), Sawyer, E.J. (Elinor J.), Schmidt, M.K. (Marjanka), Schmutzler, R.K. (Rita), Seynaeve, C.M. (Caroline), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Southey, M.C. (Melissa), Stram, D.O. (Daniel O.), Surowy, H. (Harald), Swerdlow, A.J. (Anthony ), Teo, S.-H. (Soo-Hwang), Tessier, D.C. (Daniel C.), Tomlinson, I.P. (Ian), Torres, D. (Diana), Truong, T. (Thérèse), Vachon, C. (Celine), Vincent, D. (Daniel), Winqvist, R. (Robert), Wu, A.H. (Anna), Wu, P.-E. (Pei-Ei), Yip, C.H. (Cheng Har), Zheng, W. (Wei), Pharoah, P.D.P. (Paul), Hall, P. (Per), Edwards, S.L. (Stacey), Simard, J. (Jacques), French, J.D. (Juliet), Chenevix-Trench, G. (Georgia), Dunning, A.M. (Alison) |
| المصدر: |
Scientific Reports vol. 6 |
| سنة النشر: |
2016 |
| المجموعة: |
RePub - Publications from Erasmus University, Rotterdam |
| الوصف: |
Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90-0.94; P = 8.96 × 1015)) and are |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://repub.eur.nl/pub/97459Test; urn:hdl:1765/97459 |
| DOI: |
10.1038/srep32512 |
| الإتاحة: |
https://doi.org/10.1038/srep32512Test
http://repub.eur.nl/pub/97459Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.A288F36E |
| قاعدة البيانات: |
BASE |
