دورية أكاديمية
Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
| العنوان: | Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches |
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| المؤلفون: | Velho, Tarciso André Ferreira, Lovell, Peter V, Friedrich, Samantha R, Olson, Christopher R, Miles, Joshua, Mueller, Paul A, Tavori, Hagai, Fazio, Sergio, Lois, Carlos, Mello, Claudio V |
| سنة النشر: | 2021 |
| المجموعة: | Universidade Federal do Rio Grande do Norte: Repositório Institucional (RI UFRN) |
| مصطلحات موضوعية: | Cholesterol, LDLR, VSG G, Lentivirus, Viral transduction |
| الوصف: | The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inconsistent with universal structure conservation and function across vertebrates. Linked to the LDLR functional domain loss, zebra finches show inefficient infectivity by lentiviruses (LVs) pseudotyped with VSV G, which can be rescued by the expression of human LDLR. Finches also show an atypical plasma lipid distribution that relies largely on high-density lipoprotein (HDL). These findings provide insights into the genetics and evolution of viral infectivity and cholesterol transport mechanisms in vertebrates |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | VELHO, Tarciso A. F.; LOVELL, Peter V.; FRIEDRICH, Samantha R.; OLSON, Christopher R.; MILES, Joshua; MUELLER, Paul A.; TAVORI, Hagai; FAZIO, Sergio; LOIS, Carlos; MELLO, Claudio V. Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches. Proceedings Of The National Academy Of Sciences, [S.L.], v. 118, n. 18, p. 2025167118, 26 abr. 2021. http://dx.doi.org/10.1073/pnas.2025167118Test. Disponível em: https://www.pnas.org/content/118/18/e2025167118Test. Acesso em: 2 jul. 2021.; https://repositorio.ufrn.br/handle/123456789/32808Test; https://doi.org/10.1073/pnas.2025167118Test |
| DOI: | 10.1073/pnas.2025167118 |
| الإتاحة: | https://doi.org/10.1073/pnas.2025167118Test https://repositorio.ufrn.br/handle/123456789/32808Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 Brazil ; http://creativecommons.org/licenses/by-nc-nd/3.0/brTest/ |
| رقم الانضمام: | edsbas.A22FA34B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2025167118 |
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