التفاصيل البيبلوغرافية
| العنوان: |
Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort |
| المؤلفون: |
DCOG-LATER Study Group |
| المساهمون: |
PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, SCT patientenzorg, Klinische Fysica RT, Onderzoeksgroep 7, Brain, ZL Cerebrovasculaire Ziekten Medisch |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Childhood cancer survivors, Epidemiology, Long-term complications, Subsequent malignant neoplasm, Survival, Cancer Survivors, Humans, Male, Melanoma/epidemiology, Breast Neoplasms/epidemiology, Skin Neoplasms/epidemiology, Netherlands, Survival Analysis, Adult, Female, Neoplasms, Second Primary/epidemiology, Child, Cohort Studies, Sarcoma/epidemiology, Oncology, Cancer Research, Journal Article |
| الوصف: |
Purpose: Childhood cancer survivors are at increased risk of developing subsequent malignant neoplasms (SMNs). We compared survival and clinical characteristics of survivors with SMNs (sarcoma, breast cancer, or melanoma) and a population-based sample of similar first malignant neoplasm (FMN) patients. Methods: We assembled three case series of solid SMNs observed in a cohort of 5-year Dutch childhood cancer survivors diagnosed 1963–2001 and followed until 2014: sarcoma (n = 45), female breast cancer (n = 41), and melanoma (n = 17). Each SMN patient was sex-, age-, and calendar year-matched to 10 FMN patients in the population-based Netherlands Cancer Registry. We compared clinical and histopathological characteristics by Fisher’s exact tests and survival by multivariable Cox regression and competing risk regression analyses. Results: Among sarcoma-SMN patients, overall survival [hazard ratio (HR) 1.88, 95% confidence interval (CI) 1.23–2.87] and sarcoma-specific mortality (HR 1.91, 95% CI 1.16–3.13) were significantly worse compared to sarcoma-FMN patients (foremost for soft-tissue sarcoma), with 15-year survival rates of 30.8% and 61.6%, respectively. Overall survival did not significantly differ for breast-SMN versus breast-FMN patients (HR 1.14, 95% CI 0.54–2.37), nor for melanoma-SMN versus melanoma-FMN patients (HR 0.71, 95% CI 0.10–5.00). No significant differences in tumor characteristics were observed between breast-SMN and breast-FMN patients. Breast-SMN patients were treated more often with mastectomy without radiotherapy/chemotherapy compared to breast-FMN patients (17.1% vs. 5.6%). Conclusions: Survival of sarcoma-SMN patients is worse than sarcoma-FMN patients. Although survival and tumor characteristics appear similar for breast-SMN and breast-FMN patients, treatment differs; breast-SMN patients less often receive breast-conserving therapy. Larger studies are necessary to substantiate these exploratory findings. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
image/pdf |
| اللغة: |
English |
| تدمد: |
0957-5243 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/392061Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/392061Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.A2086130 |
| قاعدة البيانات: |
BASE |
