كتاب
Peritoneal metastases of colorectal cancer:Insights from molecular and clinical perspectives
| العنوان: | Peritoneal metastases of colorectal cancer:Insights from molecular and clinical perspectives |
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| المؤلفون: | Sluiter, Nina Roelie |
| المصدر: | Sluiter , N R 2022 , ' Peritoneal metastases of colorectal cancer : Insights from molecular and clinical perspectives ' , Dr. , Vrije Universiteit Amsterdam , Amsterdam . |
| بيانات النشر: | Ridderprint |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | colorectaal carcinoom, dikke darm kanker, peritoneale metastasen, biomarkers, vroegdiagnostiek, ct DNA, moleculaire diagnotiek, patiënt selectie, beeldvorming, colorectal cancer, colorectal carcinoma, peritoneal metastases, peritoneal carcinomatosis, early detection, molecular diagnostics, patient selection, imaging |
| الوصف: | Colorectal cancer (CRC) patients with peritoneal metastases (PM) are currently treated with cytoreductive surgery (CRS) and HIPEC. This thesis primarily focuses on optimizing the preoperative work-up of CRC patients with PM. Part I Molecular insights The first part aims to provide insight in the molecular biology of colorectal PM. Chapter 2 outlines the process of peritoneal dissemination according to two phases, which could help us identify novel candidate biomarkers. Especially tumor cell adhesion to the peritoneum was considered crucial to form PM. Chapter 3 systematically reviews the functional importance of adhesion molecules and their clinical options. For patient selection, especially sLea and MUC16 were found to be of interest. α2β1 integrin antibodies, CD44 antibodies, hyaluronan-bound cytostatic agents, and EpCAM antibodies could target adhesion molecules and theoretically prevent formation of PM. Once a tumor cell has attached to the peritoneal surface, formation of PM depends on angiogenesis. In Chapter 4, we analyzed the expression of the angiogenesis-related markers VCAN, VEGF, and microvessel density in colorectal PM. The PCI, high VEGF expression, age, low epithelial VCAN expression, and lymph node metastases were associated with poor OS after CRS-HIPEC. The expression of the other angiogenesis markers HIF1α, SDF1, CXCR4, and VEGF is described in Chapter 5. The PCI, resection outcome, and VEGF expression had an independent association with OS after CRS-HIPEC. Both studies suggest that additional systemic administration of anti-VEGF agents could enhance survival. Chapter 6 provides a first step towards the clinical use of circulating tumor (ct)DNA analysis by setting out mutation-, copy number alteration- and hypermethylation markers in ctDNA to facilitate early diagnosis, prognostication, and monitoring of CRC patients. For CRC detection, copy number alterations and SEPT9 hypermethylation analysis could be promising. Regarding prognostication, mutation analysis of KRAS and APC could be of value. ... |
| نوع الوثيقة: | book |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-94-6416-959-1 94-6416-959-1 |
| العلاقة: | https://research.vu.nl/en/publications/3cb48dfe-1a5c-4558-9ff5-c5d8332a0ba0Test; urn:ISBN:9789464169591 |
| الإتاحة: | https://research.vu.nl/en/publications/3cb48dfe-1a5c-4558-9ff5-c5d8332a0ba0Test https://hdl.handle.net/1871.1/3cb48dfe-1a5c-4558-9ff5-c5d8332a0ba0Test https://research.vu.nl/ws/files/147491269/N%20R%20%20Sluiter%20-%20thesis.pdfTest https://research.vu.nl/ws/files/147491271/N%20R%20%20Sluiter%20-%20cover.pdfTest https://research.vu.nl/ws/files/147491273/N%20R%20%20Sluiter%20-%20title_page.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A206B5AB |
| قاعدة البيانات: | BASE |
| ردمك: | 9789464169591 9464169591 |
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