دورية أكاديمية
CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
| العنوان: | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
|---|---|
| المؤلفون: | Giese, APJ, Tang, Y-Q, Sinha, GP, Bowl, MR, Goldring, AC, Parker, A, Freeman, MJ, Brown, SDM, Riazuddin, S, Fettiplace, R, Schafer, WR, Frolenkov, GI, Ahmed, ZM |
| المصدر: | Nature Communications , 8 , Article 43. (2017) |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2017 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CHANNEL-LIKE PROTEINS, MAMMALIAN INNER-EAR, BIOCHEMICAL-CHARACTERIZATION, NONSYNDROMIC DEAFNESS, BULLFROGS SACCULUS, FAST ADAPTATION, ACTIN DYNAMICS, MYOSIN-XVA, CALCIUM, STEREOCILIA |
| الوصف: | Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact function is unknown. Here, we have characterized two mutant mouse lines, one lacking calcium and integrin-binding protein 2 and one carrying a human deafness-related Cib2 mutation, and show that both are deaf and exhibit no mechanotransduction in auditory hair cells, despite the presence of tip links that gate the mechanotransducer channels. In addition, mechanotransducing shorter row stereocilia overgrow in hair cell bundles of both Cib2 mutants. Furthermore, we report that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations. We conclude that calcium and integrin-binding protein 2 is required for normal operation of the mechanotransducer channels and is involved in limiting the growth of transducing stereocilia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10112372/1/CIB2%20interacts%20with%20TMC1%20and%20TMC2%20and%20is%20essential%20for%20mechanotransduction%20in%20auditory%20hair%20cells.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10112372Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10112372/1/CIB2%20interacts%20with%20TMC1%20and%20TMC2%20and%20is%20essential%20for%20mechanotransduction%20in%20auditory%20hair%20cells.pdfTest https://discovery.ucl.ac.uk/id/eprint/10112372Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.A1E1CC87 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |