دورية أكاديمية
Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas
| العنوان: | Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas |
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| المؤلفون: | Onofri, C., Carbia Nagashima, A., Schaaf, L., Feirer, M., Lohrer, P., Stummer, W., Berner, S., Chervin, A., Goldberg, V., Stalla, G.K., Renner, U., Arzt, E. |
| المجموعة: | Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
| مصطلحات موضوعية: | Estrogens, Interleukin-6, Lactotroph/lactosomatotroph adenomas, Vascular endothelial growth factor, estradiol, interleukin 6, vasculotropin, adult, article, clinical article, cytokine production, female, hormonal regulation, human, human tissue, hypophysis adenoma, male, neuroendocrinology, priority journal, protein expression, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Pituitary Neoplasms, Prolactinoma, Tumor Cells, Cultured, Vascular Endothelial Growth Factor A |
| الوصف: | Estrogens are considered to be critically involved in lactotroph and lactosomatotroph pituitary tumor development. In addition to direct effects, estradiol-induced tumor formation may involve alterations in growth factor and cytokine production. We have studied whether estradiol stimulates the production of the angiogenic vascular endothelial growth factor and the potential tumor progression factor interleukin-6 in 5 lactotroph (LA) and 5 lactosomatotroph (LSA) human pituitary adenoma cell cultures. All tumors secreted heterogenous basal amounts of VEGF (18.0 ± 1.4 to 425 ± 26 pg/ml per 24h) and IL-6 (18.1 ± 1.5 to 604 ± 17 pg/ml per 24h). Estradiol (100nM) significantly enhanced VEGF release in all LA and LSA cell cultures (47 to 168% above basal). IL-6 secretion was stimulated in 3 out of 5 LA and in all LSA cell cultures (31 to 287% above basal). In cell cultures obtained from tumors from which sufficient cells could be isolated, a dose-dependent effect of estradiol (1 to 100 nM) on VEGF and IL-6 production was observed. Stimulation of IL-6 and/or VEGF secretion by estradiol in the majority of human lactotroph and lactosomatotroph adenoma cell cultures studied, suggests that estrogens may contribute to adenoma expansion through the stimulation of these auto-/paracrine-acting adenoma progression factors. ; Fil:Carbia Nagashima, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/20.500.12110/paper_09477349_v112_n1_p18_OnofriTest |
| الإتاحة: | https://doi.org/20.500.12110/paper_09477349_v112_n1_p18_OnofriTest https://hdl.handle.net/20.500.12110/paper_09477349_v112_n1_p18_OnofriTest |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/2.5/arTest |
| رقم الانضمام: | edsbas.A1A9C9EF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |