دورية أكاديمية
Turning uridines around: Role of rRNA pseudouridylation in ribosome biogenesis and ribosomal function
| العنوان: | Turning uridines around: Role of rRNA pseudouridylation in ribosome biogenesis and ribosomal function |
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| المؤلفون: | Marianna Penzo, Lorenzo Montanaro |
| المساهمون: | Marianna Penzo, Lorenzo Montanaro |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Cancer, Internal ribosome entry site-mediated translation, MRNA translation, Pseudouridylation, Ribosome biogenesi, Ribosome diversity, RRNA, Translational control, X-linked dyskeratosis congenita, Biochemistry, Molecular Biology |
| الوصف: | Ribosomal RNA (rRNA) is extensively edited through base methylation and acetylation, 20-O-ribose methylation and uridine isomerization. In human rRNA, 95 uridines are predicted to by modified to pseudouridine by ribonucleoprotein complexes sharing four core proteins and differing for a RNA sequence guiding the complex to specific residues to bemodified. Most pseudouridylation sites are placed within functionally important ribosomal domains and can influence ribosomal functional features. Information obtained so far only partially explained the degree of regulation and the consequences of pseudouridylation on ribosomal structure and function in different physiological and pathological conditions. This short review focuses on the available evidence in this topic, highlighting open questions in the field and perspectives that the development of emerging techniques is offering. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29874862; info:eu-repo/semantics/altIdentifier/wos/WOS:000436489100025; volume:8; issue:2; firstpage:38; lastpage:47; numberofpages:10; journal:BIOMOLECULES; http://hdl.handle.net/11585/646845Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85049516279; http://www.mdpi.com/2218-273X/8/2/38/pdfTest |
| DOI: | 10.3390/biom8020038 |
| الإتاحة: | https://doi.org/10.3390/biom8020038Test http://hdl.handle.net/11585/646845Test http://www.mdpi.com/2218-273X/8/2/38/pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A1A0D69E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biom8020038 |
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