دورية أكاديمية
Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
| العنوان: | Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus |
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| المؤلفون: | Draenert, Rika, Allen, Todd M., Liu, Yang, Wrin, Terri, Chappey, Colombe, Verrill, Cori L., Sirera, Guillem, Eldridge, Robert L., Lahaie, Matthew P., Ruiz, Lidia, Clotet, Bonaventura, Petropoulos, Christos J., Walker, Bruce D., Martinez-Picado, Javier |
| المصدر: | The Journal of Experimental Medicine ; volume 203, issue 3, page 529-539 ; ISSN 1540-9538 0022-1007 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2006 |
| الوصف: | The predictability of virus–host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozygotic twins simultaneously infected with the same virus. CD4 T cell counts and viral loads followed similar trajectories over three years of follow up. The initial CD8 T cell response targeted 17 epitopes, 15 of which were identical in each twin, including two immunodominant responses. By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas all new responses were subdominant and remained so. Of four responses that declined in both twins, three demonstrated mutations at the same residue. In addition, the evolving antibody responses cross-neutralized the other twin's virus, with similar changes in the pattern of evolution in the envelope gene. These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20052116 |
| الإتاحة: | https://doi.org/10.1084/jem.20052116Test https://rupress.org/jem/article-pdf/203/3/529/1720326/529.pdfTest |
| رقم الانضمام: | edsbas.A16E1F32 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20052116 |
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