التفاصيل البيبلوغرافية
| العنوان: |
TXNIP-mediated crosstalk between oxidative stress and glucose metabolism |
| المؤلفون: |
Kim, Stephanie, Ge, Jianning, Kim, Dokyun, Lee, Jae Jin, Choi, Youn Jung, Chen, Weiqiang, Bowman, James W., Foo, Suan-Sin, Chang, Lin-Chun, Liang, Qiming, Hara, Daiki, Choi, Inpyo, Kim, Myung Hee, Eoh, Hyungjin, Jung, Jae U. |
| المساهمون: |
Mukhopadhyay, Subhadip, National Institute of Health, the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program, KRIBB Research Initiative Grant, Korean Government |
| المصدر: |
PLOS ONE ; volume 19, issue 2, page e0292655 ; ISSN 1932-6203 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2024 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation and glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR and C-ARR) domains at its amino-terminus and two PPxY (PY) motifs and a di-leucine (LL) motif for endocytosis at its carboxyl-terminus. Here, we report that TXNIP shuffles between TRX and GLUTs to regulate homeostasis of intracellular oxidative stress and glucose metabolism. While TXNIP functions as a gatekeeper of TRX by default, it robustly interacted with class I GLUTs through its C-ARR domain upon increase of intracellular reactive oxygen species. This interaction prompted the surface expression downregulation and lysosomal degradation of GLUTs by its carboxyl-terminal LL endocytic signaling motif to attenuate glucose uptake. Consequently, TXNIP expression significantly limited glucose uptake, leading to the suppression of glycolysis, hexosamine biosynthesis, and the pentose phosphate pathway. Our findings establish a fundamental link between ROS and glucose metabolism through TXNIP and provide a promising target for the drug development against GLUT-related metabolic disorders. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pone.0292655 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0292655Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A15960AD |
| قاعدة البيانات: |
BASE |
