دورية أكاديمية
Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth
| العنوان: | Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth |
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| المؤلفون: | Sameshima, Tomohiro, Ashina, Mariko, Fukuda, Takuya, Kido, Takumi, Abe, Shinya, Watanabe, Yuko, Sato, Itsuko, Yano, Yoshihiko, Tanimura, Kenji, Nagase, Hiroaki, Nozu, Kandai, Fujioka, Kazumichi |
| المساهمون: | Japan Society for the Promotion of Science |
| المصدر: | Scientific Reports ; volume 14, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age are unclear. We retrospectively analyzed infants admitted to our institution between June 1, 2018, and March 31, 2022, whose clinical and PIVKA-II data were available, and classified them into preterm and term infant groups. Overall incidence of PIVKA-II-positive cases (≥ 50 mAU/mL) was 42.8%, including 0.6% apparent VK deficiency (≥ 5000 mAU/mL), 3.1% experimental VK deficiency (1000–4999 mAU/mL), and 10.7% latent VK deficiency (200–999 mAU/mL) cases. Incidence of PIVKA-II-positive cases was significantly higher in the term group than in the preterm group (49.4% vs. 29.7%, p < 0.001). Gestational age correlated with PIVKA-II levels (r 2 = 0.117, p < 0.0001). Median serum PIVKA-II levels and incidence of PIVKA-II-positive cases (≥ 50 mAU/mL, 16.4%) were lower at 5 days after birth than at birth, possibly reflecting the postnatal VK prophylaxis impact. Only one infant was diagnosed with VK deficiency bleeding (PIVKA-II levels, at birth: 10,567 mAU/mL; at day 5: 2418 mAU/mL). Thus, serum PIVKA-II levels after birth weakly correlated with gestational age. VK deficiency was more common in term infants than in preterm infants. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-024-51674-8 |
| الإتاحة: | https://doi.org/10.1038/s41598-024-51674-8Test https://www.nature.com/articles/s41598-024-51674-8.pdfTest https://www.nature.com/articles/s41598-024-51674-8Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.A0D3A4C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-024-51674-8 |
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