دورية أكاديمية
Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia ...
| العنوان: | Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia ... |
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| المؤلفون: | Yaqub, Amber, Vojinovic, Dina, Vernooij, Meike W., Slagboom, P. Eline, Ghanbari, Mohsen, Beekman, Marian, van der Grond, Jeroen, Hankemeier, Thomas, van Duijn, Cornelia M., Ikram, M. Arfan, Ahmad, Shahzad |
| بيانات النشر: | figshare |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Medicine, Cell Biology, Neuroscience, Physiology, FOS Biological sciences, Biotechnology, Sociology, FOS Sociology, Cancer, Mental Health |
| الوصف: | Background The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, and dementia remains uncertain. Methods In the population-based Rotterdam Study, we used multivariable regression models to study the associations between plasma TMAO, its precursors, and cognition in 3,143 participants. Subsequently, we examined their link to structural brain MRI markers in 2,047 participants, with a partial validation in the Leiden Longevity Study (n = 318). Among 2,517 participants, we assessed the risk of incident dementia using multivariable Cox proportional hazard models. Following this, we stratified the longitudinal associations by medication use and sex, after which we conducted a sensitivity analysis for individuals with impaired renal function. Results Overall, plasma TMAO was not associated with cognition, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.6084/m9.figshare.c.7243967 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.c.7243967Test https://springernature.figshare.com/collections/Plasma_trimethylamine_N-oxide_TMAO_associations_with_cognition_neuroimaging_and_dementia/7243967Test |
| حقوق: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 |
| رقم الانضمام: | edsbas.A0BA1A88 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.c.7243967 |
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