التفاصيل البيبلوغرافية
| العنوان: |
Combination of liver intravoxel incoherent motion imaging with MR fat quantification at 3.0 T to distinguish between pure steatosis and NASH |
| المؤلفون: |
Leporq, B., Pilleul, F., Dumortier, J., Guillaud, O., Lefort, T., Beuf, O. |
| المساهمون: |
RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard Lyon, Département d'hépatologie, Hospices Civils de Lyon (HCL) |
| المصدر: |
European Congress of Radiology 2013 ; https://hal.science/hal-00847879Test ; European Congress of Radiology 2013, Mar 2013, Vienne, Austria. pp.B-0444 |
| بيانات النشر: |
HAL CCSD |
| سنة النشر: |
2013 |
| المجموعة: |
Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: |
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing |
| جغرافية الموضوع: |
Vienne, Austria |
| الوصف: |
International audience ; Purpose: To evaluate the combination of liver intra-voxel incoherent motion imaging (IVIM) and a MRI fat quantification method at 3.0 T to make the distinction between NASH and pure steatosis. Methods and Materials: A multi-angle multi-gradient echo acquisition combined with a dedicated algorithm was used to quantify liver fat volume fraction (FVF), corrected for water and fat relaxation times and accounting for the NMR spectrum of fat. IVIM was performed using a single-shot SE-EPI sequence, in free breathing, with 11 b-values (0-20-40-60-80-100-200-300-400-600-800s.mm-2) and a weighted signal averaging procedure. Three orthogonal diffusion gradients were sequentially applied. A 2000 ms TR, 54 ms minimum TE; 21 axial slices of 8 mm thick; 400×300 mm² FOV; 128×96 matrix were used. IVIM parameters (pure molecular diffusion coefficient (DSlow), perfusion-related diffusion coefficient (DFast) and perfusion fraction (f)) were estimated. MR imaging was performed on a healthy volunteers group (n=33), and on patients with histologically confirmed pure steatosis (n=16) or NASH (n=4). Results: Wilcoxon test showed that DSlow was significantly lower when fat is present (FVF > 5.5%) (p < 0.01). DSlow and DFast were found significantly reduced between subjects with pure steatosis (Brunt=0) and NASH (Brunt> 0) (p < 0.05). Conclusion: Fat vesicles in pure steatosis restrict molecular diffusion without modification of micro-perfusion. In NASH, fibrosis still increase the restriction of molecular diffusion compared to patients with pure steatosis and decrease the microperfusion as illustrated by the decrease of perfusion-related diffusion coefficient. These preliminary results suggest that combining MRI fat quantification and IVIM could be a none invasive mean to distinguish between pure steatosis and NASH. |
| نوع الوثيقة: |
conference object |
| اللغة: |
English |
| العلاقة: |
hal-00847879; https://hal.science/hal-00847879Test |
| الإتاحة: |
https://hal.science/hal-00847879Test |
| رقم الانضمام: |
edsbas.A050B392 |
| قاعدة البيانات: |
BASE |
