التفاصيل البيبلوغرافية
| العنوان: |
The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease |
| المؤلفون: |
Rodanthi Lyraki, Andreas Schedl |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4889 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
adrenal cortex, sexual dimorphism, sex hormones, proliferation, adrenocortical carcinoma, Cushing’s syndrome, Addison’s disease, stem cells |
| جغرافية الموضوع: |
agris |
| الوصف: |
Many adrenocortical diseases are more prevalent in women than in men, but the reasons underlying this sex bias are still unknown. Recent studies involving gonadectomy and sex hormone replacement experiments in mice have shed some light onto the molecular basis of sexual dimorphism in the adrenal cortex. Indeed, it has been shown that gonadal hormones influence many aspects of adrenal physiology, ranging from stem cell-dependent tissue turnover to steroidogenesis and X-zone dynamics. This article reviews current knowledge on adrenal cortex sexual dimorphism and the potential mechanisms underlying sex hormone influence of adrenal homeostasis. Both topics are expected to contribute to personalized and novel therapeutic approaches in the future. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms22094889Test |
| DOI: |
10.3390/ijms22094889 |
| الإتاحة: |
https://doi.org/10.3390/ijms22094889Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A02D16B1 |
| قاعدة البيانات: |
BASE |
