دورية أكاديمية
An efficient strategy to select head and neck cancer patients for adaptive radiotherapy
| العنوان: | An efficient strategy to select head and neck cancer patients for adaptive radiotherapy |
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| المؤلفون: | Gan, Yong, Langendijk, Johannes A, van der Schaaf, Arjen, van den Bosch, Lisa, Oldehinkel, Edwin, Lin, Zhixiong, Both, Stefan, Brouwer, Charlotte L |
| المصدر: | Gan , Y , Langendijk , J A , van der Schaaf , A , van den Bosch , L , Oldehinkel , E , Lin , Z , Both , S & Brouwer , C L 2023 , ' An efficient strategy to select head and neck cancer patients for adaptive radiotherapy ' , Radiotherapy and Oncology , vol. 186 , 109763 . https://doi.org/10.1016/j.radonc.2023.109763Test |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| الوصف: | BACKGROUND AND PURPOSE: Adaptive radiotherapy (ART) is workload intensive but only benefits a subgroup of patients. We aimed to develop an efficient strategy to select candidates for ART in the first two weeks of head and neck cancer (HNC) radiotherapy. MATERIALS AND METHODS: This study retrospectively enrolled 110 HNC patients who underwent modern photon radiotherapy with at least 5 weekly in-treatment re-scan CTs. A semi auto-segmentation method was applied to obtain the weekly mean dose (D mean) to OARs. A comprehensive NTCP-profile was applied to obtain NTCP's. The difference between planning and actual values of D mean (ΔD mean) and dichotomized difference of clinical relevance (BIOΔNTCP) were used for modelling to determine the cut-off maximum ΔD mean of OARs in week 1 and 2 (maxΔD mean_1 and maxΔD mean_2). Four strategies to select candidates for ART, using cut-off maxΔD mean were compared. RESULTS: The Spearman's rank correlation test showed significant positive correlation between maxΔD mean and BIOΔNTCP (p-value <0.001). For major BIOΔNTCP (>5%) of acute and late toxicity, 10.9% and 4.5% of the patients were true candidates for ART. Strategy C using both cut-off maxΔD mean_1 (3.01 and 5.14 Gy) and cut-off maxΔD mean_2 (3.41 and 5.30 Gy) showed the best sensitivity, specificity, positive and negative predictive values (0.92, 0.82, 0.38, 0.99 for acute toxicity and 1.00, 0.92, 0.38, 1.00 for late toxicity, respectively). CONCLUSIONS: We propose an efficient selection strategy for ART that is able to classify the subgroup of patients with >5% BIOΔNTCP for late toxicity using imaging in the first two treatment weeks. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/8c5bb2c9-1b60-4b2d-8ebd-312d53feec0fTest |
| DOI: | 10.1016/j.radonc.2023.109763 |
| الإتاحة: | https://doi.org/10.1016/j.radonc.2023.109763Test https://hdl.handle.net/11370/8c5bb2c9-1b60-4b2d-8ebd-312d53feec0fTest https://research.rug.nl/en/publications/8c5bb2c9-1b60-4b2d-8ebd-312d53feec0fTest https://pure.rug.nl/ws/files/736619633/1-s2.0-S0167814023003018-main.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9F741186 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.radonc.2023.109763 |
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