التفاصيل البيبلوغرافية
| العنوان: |
A novel combined miRNA and methylation marker panel (miMe) for prediction of prostate cancer outcome after radical prostatectomy |
| المؤلفون: |
Strand, Siri H., Bavafaye‐Haghighi, Elham, Kristensen, Helle, Rasmussen, Anne K., Hoyer, Soren, Borre, Michael, Mouritzen, Peter, Besenbacher, Soren, Orntoft, Torben F., Sorensen, Karina D. |
| المساهمون: |
Innovationsfonden, Kræftens Bekæmpelse, Velux Fonden |
| المصدر: |
International Journal of Cancer ; volume 145, issue 12, page 3445-3452 ; ISSN 0020-7136 1097-0215 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2019 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Improved prognostic biomarkers are needed to guide personalized prostate cancer (PC) treatment decisions. Due to the prominent molecular heterogeneity of PC, multimarker panels may be more robust. Here, 25 selected top‐candidate miRNA and methylation markers for PC were profiled by qPCR in malignant radical prostatectomy (RP) tissue specimens from 198 PC patients (Cohort 1, training). Using GLMnet, we trained a novel multimarker model (miMe) comprising nine miRNAs and three methylation markers that predicted postoperative biochemical recurrence (BCR) independently of the established clinicopathological CAPRA‐S nomogram in Cox multivariate regression analysis in Cohort 1 (HR [95% CI]: 1.53 [1.26–1.84], p < 0.001). This result was successfully validated in two independent RP cohorts (Cohort 2, n = 159: HR [95% CI]: 1.35 [1.06–1.73], p = 0.015. TCGA, n = 350: HR [95% CI]: 1.34 [1.01–1.77], p = 0.04). Notably, in CAPRA‐S low‐risk patients, a high miMe score was associated with >6 times higher risk of BCR, suggesting that miMe may help identify PC patients at high risk of progression despite favorable clinicopathological factors postsurgery. Finally, miMe was a significant predictor of cancer‐specific survival ( p = 0.019, log‐rank test) in a merged analysis of 357 RP patients. In conclusion, we trained, tested and validated a novel 12‐marker panel (miMe) that showed significant independent prognostic value in three RP cohorts. In the future, combining miMe score with existing clinical nomograms may improve PC risk stratification and thus help guide treatment decisions. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/ijc.32427 |
| الإتاحة: |
https://doi.org/10.1002/ijc.32427Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.9F585A79 |
| قاعدة البيانات: |
BASE |
