دورية أكاديمية
Daptomycin plus fosfomycin versus Daptomycin lone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial
| العنوان: | Daptomycin plus fosfomycin versus Daptomycin lone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
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| المؤلفون: | Pujol, Miquel, Montero, Maria Milagro, Carratalà, Jordi, MRSA Bacteremia (BACSARM) Trial Investigators |
| بيانات النشر: | Oxford University Press |
| المجموعة: | UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| مصطلحات موضوعية: | MRSA, Bacteremia, Clinical trial, Daptomycin, Fosfomycin |
| الوصف: | Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. Methods: A randomized (1:1) phase 3 superiority, open-label, and parallel group clinical trial of adult inpatients with MRSA bacteremia was conducted at 18 Spanish hospitals. Patients were randomly assigned to receive either 10 mg/kg of daptomycin intravenously daily plus 2 g of fosfomycin intravenously every 6 hours, or 10 mg/kg of daptomycin intravenously daily. Primary endpoint was treatment success 6 weeks after the end of therapy. Results: Of 167 patients randomized, 155 completed the trial and were assessed for the primary endpoint. Treatment success at 6 weeks after the end of therapy was achieved in 40 of 74 patients who received daptomycin plus fosfomycin and in 34 of 81 patients who were given daptomycin alone (54.1% vs 42.0%; relative risk, 1.29 [95% confidence interval, .93-1.8]; P = .135). At 6 weeks, daptomycin plus fosfomycin was associated with lower microbiologic failure (0 vs 9 patients; P = .003) and lower complicated bacteremia (16.2% vs 32.1%; P = .022). Adverse events leading to treatment discontinuation occurred in 13 of 74 patients (17.6%) receiving daptomycin plus fosfomycin, and in 4 of 81 patients (4.9%) receiving daptomycin alone (P = .018). Conclusions: Daptomycin plus fosfomycin provided 12% higher rate of treatment success than daptomycin alone, but this difference did not reach statistical significance. This antibiotic combination prevented microbiological failure and complicated bacteremia, but it was more often associated with adverse events. Clinical trials registration: NCT01898338. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1058-4838 |
| العلاقة: | Clinical Infectious Diseases. 2021 May 4;72(9):1517-25; Pujol M, Miró JM, Shaw E, Aguado JM, San-Juan R, Puig-Asensio M, et al. Daptomycin plus fosfomycin versus Daptomycin lone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial. Clin Infect Dis. 2021 May 4; 72(9): 1517-25. DOI:10.1093/cid/ciaa1081; http://hdl.handle.net/10230/47874Test; http://dx.doi.org/10.1093/cid/ciaa1081Test |
| DOI: | 10.1093/cid/ciaa1081 |
| الإتاحة: | https://doi.org/10.1093/cid/ciaa1081Test http://hdl.handle.net/10230/47874Test |
| حقوق: | Copyright © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0Test/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9F5782B6 |
| قاعدة البيانات: | BASE |
| تدمد: | 10584838 |
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| DOI: | 10.1093/cid/ciaa1081 |