دورية أكاديمية
Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis
| العنوان: | Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis |
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| المؤلفون: | Calvi A., Tur C., Chard D., Stutters J., Ciccarelli O., Cortese R., Battaglini M., Pietroboni A., De Riz M., Galimberti D., Scarpini E., De Stefano N., Prados F., Barkhof F. |
| المساهمون: | A. Calvi, C. Tur, D. Chard, J. Stutter, O. Ciccarelli, R. Cortese, M. Battaglini, A. Pietroboni, M. De Riz, D. Galimberti, E. Scarpini, N. De Stefano, F. Prado, F. Barkhof |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Black hole, Chronic active lesion, Multiple sclerosi, SEL, Volumetric MRI, Settore BIO/13 - Biologia Applicata |
| الوصف: | Background: Slowly expanding lesions (SELs) are MRI markers of chronic active lesions in multiple sclerosis (MS). T1-hypointense black holes, and reductions in magnetization transfer ratio (MTR) are pathologically correlated with myelin and axonal loss. While all associated with progressive MS, the relationship between these lesion’s metrics and clinical outcomes in relapse-onset MS has not been widely investigated. Objectives: To explore the relationship of SELs with T1-hypointense black holes, and longitudinal T1 intensity contrast ratio and MTR, their correlation to brain volume, and their contribution to MS disability in relapse-onset patients. Methods: 135 patients with relapsing-remitting MS (RRMS) were studied with clinical assessments and brain MRI (T2/FLAIR and T1-weighted scans at 1.5/3 T) at baseline and two subsequent follow-ups; a subset of 83 patients also had MTR acquisitions. Early-onset patients were defined when the baseline disease duration was ≤ 5 years (n = 85). SELs were identified using deformation field maps from the manually segmented baseline T2 lesions and differentiated from the non-SELs. Persisting black holes (PBHs) were defined as a subset of T2 lesions with a signal below a patient-specific grey matter T1 intensity in a semi-quantitative manner. SELs, PBH counts, and brain volume were computed, and their associations were assessed through Spearman and Pearson correlation. Clusters of patients according to low (up to 2), intermediate (3 to 10), or high (more than 10) SEL counts were determined with a Gaussian generalised mixture model. Mixed-effects and logistic regression models assessed volumes, T1 and MTR within SELs, and their correlation with Expanded Disability Status Scale (EDSS) and confirmed disability progression (CDP). Results: Mean age at study onset was 35.5 years (73% female), disease duration 5.5 years and mean time to last follow-up 6.5 years (range 1 to 12.5); median baseline EDSS 1.5 (range 0 to 5.5) and a mean EDSS change of 0.31 units at final follow-up. Among ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000828057500004; volume:35; firstpage:1; lastpage:9; numberofpages:9; journal:NEUROIMAGE. CLINICAL; http://hdl.handle.net/2434/943393Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85130826700 |
| DOI: | 10.1016/j.nicl.2022.103048 |
| الإتاحة: | https://doi.org/10.1016/j.nicl.2022.103048Test http://hdl.handle.net/2434/943393Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9F05A930 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.nicl.2022.103048 |
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