دورية أكاديمية
Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
| العنوان: | Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases. |
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| المؤلفون: | Peinado, María Ángeles, Ovelleiro, David, Del Moral, María Luisa, Hernández, Raquel, Martínez-Lara, Esther, Siles, Eva, Pedrajas, José Rafael, García-Martín, María Luisa, Caro, Carlos, Peralta, Sebastián, Morales, María Encarnación, Ruiz, María Adolfina, Blanco, Santos |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | MCAO, hyaluronate nanoparticles, neuroglobin, neuroprotection, proteomics, stroke, Animals, Blood-Brain Barrier, Brain Infarction, Endocytosis, Gene Ontology, Infarction, Middle Cerebral Artery, Magnetic Resonance Imaging, Male, Nanoparticles, Neurons, Neuroprotective Agents, Nitrosative Stress, Oxidative Stress, Principal Component Analysis, Rats, Wistar, Survival Analysis, Thiobarbituric Acid Reactive Substances |
| الوصف: | Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | http://hdl.handle.net/10668/21127Test; PMC8745106; https://www.mdpi.com/1422-0067/23/1/247/pdf?version=1641454198Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745106/pdfTest |
| DOI: | 10.3390/ijms23010247 |
| الإتاحة: | https://doi.org/10.3390/ijms23010247Test http://hdl.handle.net/10668/21127Test https://www.mdpi.com/1422-0067/23/1/247/pdf?version=1641454198Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745106/pdfTest |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.9EE35E91 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms23010247 |