دورية أكاديمية
Lipid droplets are a metabolic vulnerability in melanoma
| العنوان: | Lipid droplets are a metabolic vulnerability in melanoma |
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| المؤلفون: | Lumaquin-Yin, Dianne, Montal, Emily, Johns, Eleanor, Baggiolini, Arianna, Huang, Ting-Hsiang, Ma, Yilun, LaPlante, Charlotte, Suresh, Shruthy, Studer, Lorenz, White, Richard M. |
| المساهمون: | U.S. Department of Health & Human Services | National Institutes of Health, American Cancer Society, Melanoma Research Alliance |
| المصدر: | Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as well as pigmented melanocytic cells. How these different cell states relate to distinct tumorigenic phenotypes remains unclear. Here, we use a zebrafish melanoma model to identify a transcriptional program linking the melanocytic cell state to a dependence on lipid droplets, the specialized organelle responsible for lipid storage. Single-cell RNA-sequencing of these tumors show a concordance between genes regulating pigmentation and those involved in lipid and oxidative metabolism. This state is conserved across human melanoma cell lines and patient tumors. This melanocytic state demonstrates increased fatty acid uptake, an increased number of lipid droplets, and dependence upon fatty acid oxidative metabolism. Genetic and pharmacologic suppression of lipid droplet production is sufficient to disrupt cell cycle progression and slow melanoma growth in vivo. Because the melanocytic cell state is linked to poor outcomes in patients, these data indicate a metabolic vulnerability in melanoma that depends on the lipid droplet organelle. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-023-38831-9 |
| الإتاحة: | https://doi.org/10.1038/s41467-023-38831-9Test https://www.nature.com/articles/s41467-023-38831-9.pdfTest https://www.nature.com/articles/s41467-023-38831-9Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.9ECCC9D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-38831-9 |
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