دورية أكاديمية
NSE as a predictor of death or poor neurological outcome after non-shockable cardiac arrest due to any cause: Ancillary study of HYPERION trial data
| العنوان: | NSE as a predictor of death or poor neurological outcome after non-shockable cardiac arrest due to any cause: Ancillary study of HYPERION trial data |
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| المؤلفون: | Lascarrou, Jean Baptiste, Miailhe, Arnaud Félix, Le Gouge, Amélie, Cariou, Alain, Dequin, Pierre François, Reignier, Jean, Coupez, Elisabeth, Quenot, Jean Pierre, Legriel, Stéphane, Pichon, Nicolas, Thevenin, Didier, Boulain, Thierry, Frat, Jean Pierre, Vimeux, Sylvie, Colin, Gwenhaël, Desroys Du Roure, François |
| المساهمون: | AfterROSC Network Group Paris, Centre d’Investigation Clinique Tours CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional d'Orléans (CHRO), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers = University of Poitiers (UP), Funded by the District Hospital Centre, La Roche Sur Yon, France and by Laerdal Fondation, Stavenger, Norway. |
| المصدر: | ISSN: 0300-9572 ; Resuscitation ; https://hal.science/hal-03127522Test ; Resuscitation, 2021, 158, pp.193-200. ⟨10.1016/j.resuscitation.2020.11.035⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | Biomarkers/blood, Brain ischaemia/enzymology, Hypothermia, Induced, Multicentre study, Out-of-hospital cardiac arrest/complications, Out-of-hospital cardiac arrest/mortality, Prospective studies, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Purpose: Prognostication of hypoxic-ischaemic brain injury after resuscitation from cardiac arrest is based on a multimodal approach including biomarker assays. Our goal was to assess whether plasma NSE helps to predict day-90 death or poor neurological outcome in patients resuscitated from cardiac arrest in non-shockable rhythm. Methods: All included patients participated in the randomised multicentre HYPERION trial. Serum blood samples were taken 24, 48, and 72 h after randomisation; pre-treated, aliquoted, and frozen at −80 °C at the study sites; and shipped to a central biology laboratory, where the NSE assays were performed. Primary outcome was neurological status at day 90 assessed by Cerebral Performance Category (1 or 2 versus. 3, 4 or 5). Results: NSE was assayed in 235 assessable blood samples from 101 patients. In patients with good versus poor outcomes, median NSE values at 24, 48, and 72 h were 22.6 [95%CI, 14.6;27.3] ng/mL versus 33.6 [20.5;90.0] ng/mL (p < 0.04), 18.1 [11.7;29.7] ng/mL versus 76.8 [21.5;206.6] ng/mL (p < 0.0029), and 9 [6.1;18.6] ng/mL versus 80.5 [22.9;236.1] ng/mL (p < 0.001), respectively. NSE at 48 and 72 h predicted the neurological outcome with areas under the receiver-operating curve of 0.79 [95%CI, 0.69;0.96] and 0.9 [0.81;0.96], respectively. NSE levels did not differ significantly between the groups managed at 33°C and 37°C (p = 0.59). Conclusions: Data from a multicentre trial on cardiac arrest with a non-shockable rhythm due to any cause confirm that NSE values at 72 h are associated with 90-day outcome. NSE levels did not differ significantly according to the targeted temperature. Registration Identifier: ClinicalTrial NCT02722473. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33301887; hal-03127522; https://hal.science/hal-03127522Test; PUBMED: 33301887 |
| DOI: | 10.1016/j.resuscitation.2020.11.035 |
| الإتاحة: | https://doi.org/10.1016/j.resuscitation.2020.11.035Test https://hal.science/hal-03127522Test |
| رقم الانضمام: | edsbas.9EC9F4B7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.resuscitation.2020.11.035 |
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