دورية أكاديمية
Osteoclast differentiation in rheumatoid arthritis
| العنوان: | Osteoclast differentiation in rheumatoid arthritis |
|---|---|
| المؤلفون: | Kazuhiro Yokota |
| المصدر: | Immunological Medicine, Pp 1-6 (2023) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Rheumatoid arthritis, osteoclast, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor alpha, interleukin-6, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Osteoclasts, derived from the monocyte/macrophage line of bone marrow hematopoietic stem cell progenitors, are the sole bone-resorbing cells of the body. Conventional osteoclast differentiation requires macrophage colony-stimulating factor and receptor activator of nuclear factor kappa-B ligand (RANKL) signaling. Rheumatoid arthritis (RA) is the most prevalent systemic autoimmune disease and inflammatory arthritis characterized by bone destruction. Increased levels of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), in the serum and joints, cause excessive bone destruction. We have recently reported that stimulation of human peripheral blood monocytes with TNF-α and IL-6 induces the differentiation of osteoclasts with bone resorption activity. This review presents the functional differences between representative osteoclasts, conventional RANKL-induced osteoclasts, and recently identified proinflammatory cytokine (TNF-α and IL-6)-induced osteoclasts in RA patients. We believe novel pathological osteoclasts associated with RA will be identified, and new therapeutic strategies will be developed to target these osteoclasts and prevent the progression of bone destruction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2578-5826 |
| العلاقة: | https://doaj.org/toc/2578-5826Test; https://doaj.org/article/d901cf414b30444b96f2754593c5a64cTest |
| DOI: | 10.1080/25785826.2023.2220931 |
| الإتاحة: | https://doi.org/10.1080/25785826.2023.2220931Test https://doaj.org/article/d901cf414b30444b96f2754593c5a64cTest |
| رقم الانضمام: | edsbas.9EA988E9 |
| قاعدة البيانات: | BASE |
| تدمد: | 25785826 |
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| DOI: | 10.1080/25785826.2023.2220931 |