دورية أكاديمية
Clinical epidemiology of COVID-19 among hospitalized children in rural western Kenya
| العنوان: | Clinical epidemiology of COVID-19 among hospitalized children in rural western Kenya |
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| المؤلفون: | Tsegaye, AT, Sherry, C, Oduol, C, Otieno, J, Rwigi, D, Masheti, M, Machura, I, Liru, M, Akuka, J, Omedo, D, Symekher, S, Khamadi, SA, Isaaka, L, Ogero, M, Mumelo, L, Berkley, JA, Agweyu, A, Walson, JL, Singa, BO, Tickell, KD |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2024 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | The epidemiology of pediatric COVID-19 in sub-Saharan Africa and the role of fecal-oral transmission in SARS-CoV-2 are poorly understood. Among children and adolescents in Kenya, we identify correlates of COVID-19 infection, document the clinical outcomes of infection, and evaluate the prevalence and viability of SARS-CoV-2 in stool. We recruited a prospective cohort of hospitalized children aged two months to 15 years in western Kenya between March 1 and June 30 2021. Children with SARS-CoV-2 were followed monthly for 180-days after hospital discharge. Bivariable logistic regression analysis was used to identify the clinical and sociodemographics correlates of SARS-CoV-2 infection. We also calculated the prevalence of SARS-CoV-2 detection in stool of confirmed cases. Of 355 systematically tested children, 55 (15.5%) were positive and were included in the cohort. The commonest clinical features among COVID-19 cases were fever (42/55, 76%), cough (19/55, 35%), nausea and vomiting (19/55, 35%), and lethargy (19/55, 35%). There were no statistically significant difference in baseline sociodemographic and clinical characteristics between SARS-CoV-2 positive and negative participants. Among positive participants, 8/55 (14.5%, 95%CI: 5.3%-23.9%) died; seven during the inpatient period. Forty-nine children with COVID-19 had stool samples or rectal swabs available at baseline, 9 (17%) had PCR-positive stool or rectal swabs, but none had SARS-CoV-2 detected by culture. Syndromic identification of COVID-19 is particularly challenging among children as the presenting symptoms and signs mirror other common pediatric diseases. Mortality among children hospitalized with COVID-19 was high in this cohort but was comparable to mortality seen with other common illnesses in this setting. Among this small set of children with COVID-19 we detected SARS-CoV-2 DNA, but were not able to culture viable SARs-CoV-2 virus, in stool. This suggests that fecal transmission may not be a substantial risk in children recently diagnosed and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:6cf1ff1a-a18b-45f2-9761-dab6fa92ac05Test; https://doi.org/10.1371/journal.pgph.0002011Test |
| DOI: | 10.1371/journal.pgph.0002011 |
| الإتاحة: | https://doi.org/10.1371/journal.pgph.0002011Test https://ora.ox.ac.uk/objects/uuid:6cf1ff1a-a18b-45f2-9761-dab6fa92ac05Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC Public Domain Dedication (CC0) |
| رقم الانضمام: | edsbas.9E501993 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgph.0002011 |
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